论文

[1]Zhang Zongxin, Du Xingde, Zhang Shiyu, Liu Haohao, Fu Yu, Wang Fufang, Zhang Huizhen*. Adverse effects of microcystins on sperm: A systematic review. Toxicology. 2023; 490:153507.

[2]Guo Xing, Meng Ruiyang, Liu Junjie, Zhang Shiyu, Liu Haohao, Du Xingde, Zhang Huizhen*, Li Yushan. Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway. Ecotoxicol Environ Saf. 2023; 256:114845.

[3]Du Xingde, Fu Yu, Tian Zhihui, Liu Haohao, Xin Hongxia, Fu Xiaoli, Wang Fufang, Zhang Huizhen*, Zeng Xin. Microcystin-LR accelerates follicular atresia in mice via JNK-mediated adherent junction damage of ovarian granulosa cells. Ecotoxicol Environ Saf. 2023; 252:114592.

[4]Yuan Shumeng, Du Xingde, Liu Haohao, Guo Xing, Zhang Bingyu, Wang Yongshui, Wang Bingqian, Zhang Huizhen*, Guo Hongxiang. Association between bisphenol A exposure and thyroid dysfunction in adults: a systematic review and meta-analysis. Toxicol Ind Health. 2023; 39(4):188-203.

[5]Du Xingde, Liu, Haohao, Tian Zhihui, Zhang, Shiyu, Shi Linjia, Wang Yongshui, Guo Xing, Zhang Bingyu, Yuan Shumeng, Zeng Xin, Zhang Huizhen*. PI3K/AKT/mTOR pathway mediated-cell cycle dysregulation contribute to malignant proliferation of mouse spermatogonia induced by microcystin-leucine arginine. Environ Toxicol. 2023 Feb;38(2):343-358.

[6]Zhang Shiyu, Liu Haohao, Du Xingde, Chen Xinghai, Petlulu Pavankumar, Tian Zhihui, Shi Linjia, Zhang Bingyu, Yuan Shumeng, Guo Xing, Wang Yongshui, Guo Hongxiang, Zhang Huizhen*. A new identity of microcystins: Environmental endocrine disruptors? An evidence-based review. Sci Total Environ. 2022; 851(Pt 2):158262.

[7]Liu Haohao, Zeng Xin, Ma Ya, Chen Xinghai, Losiewicz Michael D, Du Xingde, Tian Zhihui, Zhang Shiyu, Shi Linjia, Zhang Huizhen*, Yang Fei. Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway. Ecotoxicol Environ Saf. 2022; 236:113454.

[8]Liu Haohao, Zeng Xin, Wang Yueqin, Losiewicz Michael D, Chen Xinghai, Du Xingde, Wang Yongshui, Zhang Bingyu, Guo Xing, Yuan Shumeng, Yang Fei, Zhang Huizhen*. Chronic Exposure to Environmentally Relevant Concentrations of Microcystin-Leucine Arginine Causes Lung Barrier Damage through PP2A Activity Inhibition and Claudin1 Ubiquitination. J Agric Food Chem. 2022;70(35):10907-10918.

[9]Ma Ya, Liu Haohao, Du Xingde, Shi Ziang, Liu Xiaohui, Wang Rui, Zhang Shiyu, Tian Zhihui, Shi Linjia, Guo Hongxiang, Zhang Huizhen*. Advances in the toxicology research of microcystins based on Omics approaches. Environ Int. 2021,154:106661.

[10]Liu Haohao, Tian Zhihui, Guo Yaxin, Liu Xiaohui, Ma Ya, Du Xingde, Wang Rui, Zhang Shiyu, Shi Linjia, Guo Hongxiang, Zhang Huizhen*. Microcystin-leucine arginine exposure contributes to apoptosis and follicular atresia in mice ovaries by endoplasmic reticulum stress-upregulated Ddit3. Sci Total Environ. 2021,756: 144070.

[11]Zhang Shiyu, Du Xingde, Liu Haohao, Losiewicz Michael D, Chen Xinghai, Ma Ya, Wang Rui, Tian Zhihui, Shi Linjia, Guo Hongxaing, Zhang Huizhen*. The latest advances in the reproductive toxicity of microcystin-LR. Environ Res. 2021,192: 110254.

[12]Du Xingde, Liu Haohao, Liu Xiaohui, Chen Xinghai, Yuan Le, Ma Ya, Huang Hui, Wang Yueqin, Wang Rui, Zhang Shiyu, Tian Zhihui, Shi Linjia, Zhang Huizhen*. Microcystin-LR induces ovarian injury and apoptosis in mice via activating apoptosis signal-regulating kinase 1-mediated P38/JNK pathway. Ecotoxicol Environ Saf. 2021, 213: 112066.

[13]Tian Zhihui, Liu Haohao, Chen Xinghai, Losiewicz Michael D, Wang Rui, Du Xingde, Wang Bingqian, Ma Ya, Zhang Shiyu, Shi Linjia, Guo Xing, Wang Yongshui, Zhang Bingyu, Yuan Shumeng, Zeng Xin, Zhang Huizhen*. The activated ATM/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells. Ecotoxicol Environ Saf. 2021, 20;227:112919.

[14]Ma Ya, Liu Haohao, Du Xingde, Petlulu Pavankumar, Chen Xinghai, Wang Rui, Zhang Shiyu, Tian Zhihui, Shi Linjia, Guo Hongxiang, Zhang Huizhen*. IRE1 and CaMKKβ pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells. Food Chem Toxicol. 2021, 147:111911.

[15]Shi Linjia, Du Xingde, Liu Haohao, Chen Xinghai, Ma Ya, Wang Rui, Tian Zhihui, Zhang Shiyu, Guo Hongxiang, Zhang Huizhen*. Update on the adverse effects of microcystins on the liver. Environ Res. 2021,195:110890.

[16]Wang Rui, Liu Haohao, Du Xingde, Ma Ya, Tian Zhihui, Zhang Shiyu, Shi Linjia, Guo Hongxiang, Zhang Huizhen*. MicroRNA-122 overexpression promotes apoptosis and tumor suppressor gene expression induced by microcystin-leucine arginine in mouse liver. Int J Environ Health Res. 2021, 28:1-12

[17]Wang Rui, Liu Xiaohui, Wu Jinxia, Liu Haohao, Wang Wenjun, Chen Xinghai, Yuan Le, Wang Yueqin, Du Xingde, Ma Ya, Losiewicz Michael D, Zhang Xiaofeng, Zhang Huizhen*. Role of microRNA-122 in microcystin-leucine arginine-induced dysregulation of hepatic iron homeostasis in mice. Environ Toxicol. 2020,10.1002.

[18]Wang Yueqin, Liu Haohao, Liu Xiaohui, Zhang Xiaofeng, Wu Jinxia, Yuan Le, Du Xingde, Wang Rui, Ma Ya, Chen Xinghai, Cheng Xuemin, ZhuangDonggang, Zhang Hhuizhen*. Histone acetylation plays an important role in MC-LR-induced apoptosis and cycle disorder in SD rat testicular cells. Chemosphere. 2020, 241:125073.

[19]Yuan Le, Liu Haoao, Liu Xiaohui, Zhang Xiaofeng, Wu Jinxia, Wang Yueqin, Du Xingde, Wang Rui, Ma Ya, Chen Xinghai, Petlulu Pavankumar, Cheng Xuemin, ZhuangDonggang, GuoHongxiang, Zhang Huizhen*. Epigenetic modification of H3K4 and oxidative stress are involved in MC-LR-induced apoptosis in testicular cells of SD rats. Environ Toxicol. 2020, 35(2):277-291.

[20]Du Xingde, Liu Haohao, Yuan Le, Wang Yueqin, Ma Ya, Wang Rui, Chen Xinghai, Losiewicz Michael D, Guo Hongxiang, Zhang Huizhen*. The Diversity of Cyanobacterial Toxins on Structural Characterization, Distribution and Identification: A Systematic Review. Toxins (Basel). 2019, 11(9), 530.

[21]Wu Jinxia, Liu Haohao, Huang Hui, Yuan Le, Liu Chuanrui, Wang Yueqin, Cheng Xuemin, ZhuangDonggang, Xu Min, Chen Xinghai, Losiewicz Michael D, Zhang Huizhen*. p53-Dependent pathway and the opening of mPTP mediate the apoptosis of co-cultured Sertoli-germ cells induced by microcystin-LR. Environ Toxicol. 2019, 34(10):1074-1084.

[22]Ma Ya, Liu Haohao, Wu Jinxia, Yuan Le, Wang Yueqin, Du Xingde, Wang Rui, Marwa PW, Petlulu Pavankumar, Chen Xinghai, Zhang Huizhen*. The adverse health effects of bisphenol A and related toxicity mechanisms. Environ Res. 2019, 176:108575.

[23]Liu Haohao, Zhang Shenshen, Liu Chuanrui, Wu Jinxia, Wang Yueqin, Yuan Le, Du Xxingde, Wang Rui, Marwa PW, Zhuang Donggang, Cheng Xuemin, Zhang Huizhen*. Resveratrol Ameliorates Microcystin-LR-Induced Testis Germ Cell Apoptosis in Rats via SIRT1 Signaling Pathway Activation. Toxins (Basel). 2018, 10(6):235.

[24]Liu Haohao, Zhang Xiaofeng, Zhang Shenshen, Huang Hui, Wu Jinxia, Wang Yueqin, Yuan Le, Liu Chuanrui, ZengXin, Cheng Xuemin, Zhuang Donggang, Zhang Huizhen*. Oxidative Stress Mediates Microcystin-LR-Induced Endoplasmic Reticulum Stress and Autophagy in KK-1 Cells and C57BL/6 Mice Ovaries. Front Physiol. 2018, 9:1058.

[25]Wu Jinxia, Yang Lei, Zhang Xiaofeng, Li Yang, Wang J, Zhang Shenshen, Liu Haohao, Huang Hui, Wang Yueqin, Yuan Le, Cheng Xuemin, Zhuang Donggang, Zhang Huizhen*, Chen Xinghai. MC-LR induces dysregulation of iron homeostasis by inhibiting hepcidin expression: A preliminary study. Chemosphere. 2018, 212:572-584.

[26]Huang Hui, Liu Chuanrui, Fu Xiaoli, Zhang Shenshen, XinYongjuan, Li Yang, XueLijian, Cheng Xuemin, Zhang Huizhen*. Microcystin-LR Induced Apoptosis in Rat Sertoli Cells via the Mitochondrial Caspase-Dependent Pathway: Role of Reactive Oxygen Species. Front Physiol. 2016, 7:397.

[27]Zhang Shenshen, Liu Chuanrui, Li Yang, Imam MU, Huang Hui, Liu Haohao, XinYongjuan, Zhang Huizhen*. Novel Role of ER Stress and Autophagy in Microcystin-LR Induced Apoptosis in Chinese Hamster Ovary Cells. Front Physiol. 2016, 7:527.

著作

[1]《微囊藻毒素的生殖毒理学》，郑州大学出版社，2021  主编

[2]《卫生防疫》 中国人事出版社 2006.07  主编

[3]《预防艾滋病健康教育读本》华文出版社 2005.09 主编

[4]《公共卫生课程思政精品教案集》 郑州大学出版社 2021.8  参编

[5]《蓝藻毒素污染与健康》 湖北科学技术出版社 2020.06  参编

[6]《妇幼保健与卫生防疫》 郑州大学出版社 2011.04  参编

[7]《职业卫生与职业医学》 人民卫生出版社 2006.07 参编

[8]《预防医学》 人民军医出版社 2004.04  参编

[9]《河南省青少年体质健康状况研究报告》 河南人民出版社 2008.03  参编

发明专利和软著

[1]张慧珍等，一种氯苯并恶唑衍生物或其药学上可接受的盐及其应用；2022-09

[2]张慧珍等，[(吲哚-3-基)嘧啶-2-基]氨基苯基丙-2-烯酰胺衍生物及盐、制备方法、应用；2018-07

[3]张慧珍等，微囊藻毒素人类暴露风险预测系统；2023-11

[4]张慧珍等，微囊藻毒素-LR所致卵巢早衰的智能筛查系统；2023-11

[5]张慧珍等，微囊藻毒素体内代谢动力学分析系统；2023-10

[6]张慧珍等，血中微囊藻毒素时间变异性分析系统；2023-10

[7]张慧珍等，干眼症环境影响因素甄别系统；2023-10

[8]张慧珍等，环境毒物与雌性不孕相关性鉴别系统；2023-10

[9]张慧珍等，卵巢早衰高风险预测模型系统；2023-06

[10]张慧珍等，孕妇性激素水平动态监测系统；2023-06

[11]张慧珍等，高敏感性卵巢储备功能预测系统；2023-06

[12]张慧珍等，多维度卵泡质量分析评价系统；2023-06

会议报告

[1]2021-2022中国环境与健康学术会议：微囊藻毒素-LR长期暴露对小鼠血睾屏障的影响及机制（2021年，兰州），分会场报告

[2]中国毒理学会神经毒理专业委员会与表观遗传毒理专业委员会2021年联合学术年会：组蛋白修饰在微囊藻毒素诱导大鼠睾丸细胞凋亡和周期阻滞中的作用及机制（2021年，江西），分会场报告

[3]环境与公共健康学术会议-暨中国环境科学学会环境健康医学与健康分会、中国毒理学会生化与脑子毒理专业委员会2017年年会：微囊藻毒素对生殖系统的毒性作用（2017年，广州），分会场报告