丁丽华
副教授、硕士生导师
研究方向:生物样品分析新方法新技术
联系电话:-
邮箱:zzulihuading@zzu.edu.cn

论文

[1]Wu Y#, Gao ZB#, Chai YR, He ST, Liu X, Yuan HJ, Tan LL, Ding LH*, Wu YJ*. One-step and label-free ratiometric fluorescence assay for the detection of plasma exosome towards cancer diagnosis, Talanta, 2024, 271: 125700.

[2]Ding LH, Cao SN, Qu CL, Wu YJ, Yu SC*, A ratiometric CRlSPR/Cas12a-triggered CHA system coupling with MSRE to detect site-specifc DNA methylation, ACS Sensors, 2024, 9(4):1877-1885.

[3]Ding LH, Liu X, Zhang ZZ, Liu LE, He ST, Wu Y, Effah YC, Yang RY, Zhang AA, Chen WS, Yarmamat M, Qu LB*, Yang XN*, Wu YJ*. Magnetic-nanowaxberry-based microfluidic ExoSIC for affinity and continuous separation of circulating exosomes towards cancer diagnosis. Lab on a Chip 2023, 23: 1694-1702.

[4]Ding LH, Wu Y, Liu LE, He LL, Yu SC, Effah YC, Liu X, Qu LB*, Wu YJ*. Universal DNAzyme walkers-triggered CRISPR-Cas12a/Cas13a bioassay for the synchronous detection of two exosomal proteins and its application in intelligent diagnosis of cancer. Biosensors and Bioelectronics 2023, 219:114827.

[5]He ST#,Ding LH#, Yuan HJ, Zhao GF*, Yang XN*, Wu YJ*. A review of sensors for classification and subtype discrimination of cancer: Insights into circulating tumor cells and tumor-derived extracellular vesicles. Analytica Chimica Acta 2023, 1244: 340703.

[6]Ding LH, Yang XN, Gao ZB, Effah YC, Zhang XJ, Wu YJ* Qu LB*. A holistic review of the state-of-the-art microfluidis for exosome separation: An overview of the current status, existing obstacles, and future outlook. Small 2021, 17(29): 2007174.

[7]Ding LH, Liu LE, He LL, Effah YC, Yang RY, Ouyang DX, Jian NG, Liu X, Wu YJ*, Qu LB*. Magnetic-nanowaxberry-based simultaneous detection of exosome and exosomal proteins for the intelligent diagnosis of cancer. Analytical Chemistry 2021, 93(45):15200-15208.

[8]Ding LH, Wu YJ, Duan YJ, Yu SC, Yu F, Wang J, Tian YM, Gao ZB, Wan ZZ, He LL*. A novel cell-assisted enhanced chemiluminescence strategy for rapid and label-free detection of tumor cells in whole blood. ACS Sensors 2020, 5(2): 440-446.

[9]Ding LH, Chen X, He LL, Yu F, Yu SC, Wang J, Tian YM, Wang YL, Wu YJ*, Liu LE*, Qu LB*. Fluorometric immunoassay for the simultaneous determination of the tumor markers carcinoembryonic antigen and cytokeratin 19 fragment using two kinds of CdSe/ZnS quantum dot nanobeads and magnetic beads. Microchimica Acta 2020, 187(3): 171.

[10]Ding LH, Wu YJ, Liu W, Liu LE, Yu F, Yu SC, Tian YM, Feng JD, He LL*. Magnetic-assisted self-assembled aptamer/protein hybrid probes for efficient capture and rapid detection of cancer cells in whole blood. Talanta 2019, 205: 120129.

专利

[1] 丁丽华 (第二发明人),一种自组装聚HRP探针、制备方法、试剂盒及其应用,2020-02-07,中国,ZL 201710929595.2

[2] 丁丽华 (第二发明人),血浆外泌体浓度和外泌体膜蛋白浓度的同步检测方法,2023-07-21,中国,ZL 202111143245.6

[3] 丁丽华 (第一发明人),基于 CRISPR/Cas12a 和 HCR 的小胞外囊泡比色/化学发光双模式传感器及其应用,2024-06-18,中国,CN 202410788619.7

[4] 丁丽华 (第二发明人),多种外泌体蛋白的同步检测方法,2022-06-24,中国,CN 202210729128.6

学术奖励

[1]丁丽华(2/10),肺癌筛查与早期诊断关键技术研究及应用。河南省科学技术进步奖二等奖,2024。

[2] 丁丽华(2/3),Self-assembled poly-HRP dual signal amplification strategy for high-sensitive detection of circulating miR-142-3p in human serum。河南省教育厅科技成果奖优秀科技论文奖一等奖,2024。

[3] 丁丽华(2/3),医理工交叉学科博士研究生培养模式探索与实践。河南省教育科学研究优秀成果奖二等奖,2023。

[4] 第十六届“挑战杯”河南省大学生课外学术科技作品竞赛,省级一等奖,指导教师。