张慧珍
二级教授、博士生导师、河南省特聘教授、河南省高层次人才、中原科技创新领军人才、郑州大学学科特聘教授
研究方向:环境与生殖健康、环境相关疾病与健康评价、新污染物健康效应及机制、环境流行病学与环境毒理学
联系电话:-
邮箱:huizhenzhang@zzu.edu.cn

近五年代表性论文(*表示通讯作者)

[1]Zhang Huizhen*. Short Chain Chlorinated Paraffins Impaired Spermatogenesis Process in Mice via Inhibiting α-KG/TET Enzyme Activity, Environ Sci Technol, 2024, 58(39): 17270-17282.(中科院一区,TOP期刊,IF=10.8)

[2]Zhang Huizhen*. Co-exposure of microcystin and nitrite enhanced spermatogenic disorders: The role of mtROS-mediated pyroptosis and apoptosis. Environ Int, 2024; 188: 108771.(中科院一区,TOP期刊,IF=10.3)

[3]Zhang Huizhen*. A new identity of microcystins: Environmental endocrine disruptors? An evidence-based review. Sci Total Environ. 2022; 851(Pt 2):158262.(中科院一区,TOP期刊,IF=10.754)

[4]Zhang Huizhen*. Advances in the toxicology research of microcystins based on Omics approaches. Environ Int. 2021,154:106661.(中科院一区,TOP期刊,IF=13.365)

[5]Zhang Huizhen*. Microcystin-leucine arginine exposure contributes to apoptosis and follicular atresia in mice ovaries by endoplasmic reticulum stress-upregulated Ddit3. Sci Total Environ. 2021,756: 144070.(中科院一区,TOP期刊,IF=10.753)

[6]Huizhen Zhang*. Nicotinamide Alleviates Synergistic Impairment of Intestinal Barrier Caused by MC-LR and NaNO2 Coexposure, J Agric Food Chem, 2024, 72(43):24024-24034.(中科院一区,TOP期刊,IF=5.7)

[7]Zhang Huizhen*. Environmentally related microcystin-LR-induced ovarian dysfunction via the CCL2-CCR10 axis in mice ameliorated by dietary mulberry. Environ Pollut. 2024; 349: 123929.(中科院二区,TOP期刊,IF=7.6)

[8]Zhang Huizhen*. The effect and mechanism of combined exposure of MC-LR and NaNO2 on liver lipid metabolism. Environ Res. 2024; 252: 119113.(中科院一区,TOP期刊,IF=7.7)

[9]Zhang Huizhen*. Advances in polychlorinated biphenyls-induced female reproductive toxicity. Sci Total Environ. 2024; 918: 170543.(中科院一区,TOP期刊,IF=8.2)

[10]Zhang Huizhen*. The cytotoxicity of microcystin-LR: ultrastructural and functional damage of cells. Arch Toxicol. 2024; 98(3) 663-687.(中科院一区,IF=4.8)

[11]Zhang Huizhen*. Does climate change increase the risk of marine toxins? Insights from changing seawater conditions. Arch Toxicol.2024.(中科院一区,IF=4.8)

[12]Zhang Huizhen*. Microcystin leucine arginine induces human sperm damage: Involvement of the Ca2+/CaMKKβ/AMPK pathway. Ecotoxicol Environ Saf. 2023; 256:114845.(中科院一区,TOP期刊,IF=7.129)

[13]Zhang Huizhen*. Microcystin-LR accelerates follicular atresia in mice via JNK-mediated adherent junction damage of ovarian granulosa cells. Ecotoxicol Environ Saf. 2023; 252:114592.(中科院一区,TOP期刊,IF=6.8)

[14]Zhang Huizhen*. Association between bisphenol A exposure and thyroid dysfunction in adults: a systematic review and meta-analysis. Toxicol Ind Health. 2023; 39(4):188-203.(中科院四区,IF=1.851)

[15]Zhang Huizhen*. PI3K/AKT/mTOR pathway mediated-cell cycle dysregulation contribute to malignant proliferation of mouse spermatogonia induced by microcystin-leucine arginine. Environ Toxicol. 2023;38(2):343-358.(中科院二区,IF=4.1)

[16]Zhang Huizhen*. Adverse effects of microcystins on sperm: A systematic review. Toxicology. 2023; 490:153507. (中科院二区,IF=4.5)

[17]Zhang Huizhen*. Chronic Exposure to Environmentally Relevant Concentrations of Microcystin-Leucine Arginine Causes Lung Barrier Damage through PP2A Activity Inhibition and Claudin1 Ubiquitination. J Agric Food Chem. 2022;70(35): 10907-10918.(中科院一区,TOP期刊,IF=5.895)

[18]Zhang Huizhen*. Long-term exposure to low concentrations of MC-LR induces blood-testis barrier damage through the RhoA/ROCK pathway. Ecotoxicol Environ Saf. 2022; 236:113454.(中科院一区,TOP期刊,IF=7.129)

[19]Zhang Huizhen*. IRE1 and CaMKKβ pathways to reveal the mechanism involved in microcystin-LR-induced autophagy in mouse ovarian cells. Food Chem Toxicol. 2021, 147:111911.(中科院一区,IF=5.572)

[20]Zhang Huizhen*. Microcystin-LR induces ovarian injury and apoptosis in mice via activating apoptosis signal-regulating kinase 1-mediated P38/JNK pathway. Ecotoxicol Environ Saf. 2021, 213: 112066.(中科院一区,TOP期刊,IF=7.129)

[21]Zhang Huizhen*. The activated ATM/p53 pathway promotes autophagy in response to oxidative stress-mediated DNA damage induced by Microcystin-LR in male germ cells. Ecotoxicol Environ Saf. 2021, 20;227:112919.(中科院一区,TOP期刊,IF=7.129)

[22]Zhang Huizhen*. Update on the adverse effects of microcystins on the liver. Environ Res. 2021,195:110890.(中科院二区,TOP期刊,IF=8.431)

[23]Zhang Huizhen*. MicroRNA-122 overexpression promotes apoptosis and tumor suppressor gene expression induced by microcystin-leucine arginine in mouse liver. Int J Environ Health Res. 2021, 28:1-12.(中科院四区,IF=4.477)

[24]Zhang Huizhen*. The latest advances in the reproductive toxicity of microcystin-LR. Environ Res. 2021,192: 110254.(中科院二区,TOP期刊,IF=8.431)

[25]Zhang Huizhen*. Role of microRNA-122 in microcystin-leucine arginine-induced dysregulation of hepatic iron homeostasis in mice. Environ Toxicol. 2020,10.1002.(中科院二区,IF=4.119)

[26]Zhang Hhuizhen*. Histone acetylation plays an important role in MC-LR-induced apoptosis and cycle disorder in SD rat testicular cells. Chemosphere. 2020, 241:125073.(中科院二区,TOP期刊,IF=7.086)

[27]Zhang Huizhen*. Epigenetic modification of H3K4 and oxidative stress are involved in MC-LR-induced apoptosis in testicular cells of SD rats. Environ Toxicol. 2020, 35(2):277-291.(中科院二区,IF=4.119)

著作

[1]张慧珍(主编),《微囊藻毒素的内分泌干扰效应研究进展》 郑州大学出版社,2024

[2]张慧珍(主编),《微囊藻毒素的生殖毒性》 郑州大学出版社,2022.05  

[3]张慧珍(主编),《卫生防疫》 中国人事出版社 2006.07  

[4]张慧珍(主编),《预防艾滋病健康教育读本》华文出版社 2005.09

[5]张慧珍(编委),《预防医学》 江苏凤凰科技出版社,2024.01

[6]张慧珍(编委),《公共卫生课程思政精品教案集》 郑州大学出版社 2021.08  

[7]张慧珍(编委),《蓝藻毒素污染与健康》 北科学技术出版社 2020.06  

[8]张慧珍(编委),《妇幼保健与卫生防疫》 郑州大学出版社 2011.04  

[9]张慧珍(编委),《河南省青少年体质健康状况研究报告》 河南人民出版社 2008.03  

[10]张慧珍(编委),《职业卫生与职业医学》 人民卫生出版社 2006.07

[11]张慧珍(编委),《预防医学》 人民军医出版社 2004.04  

发明专利

[1] 张慧珍(第一发明人),一种氯苯并恶唑衍生物或其药学上可接受的盐及其应用;2022.09,

[2] 张慧珍(第一发明人),[(吲哚-3-基)嘧啶-2-基]氨基苯基丙-2-烯酰胺衍生物及盐、制备方法、应用;2021.06,