基本介绍

张嘉，副研究员，硕士生导师。主要从事环境污染物的暴露组学和健康效应研究，基于质谱的对环境和人体中的环境污染物的筛查分析并利用多组学解析污染物的毒性健康效应。主持国家自然科学基金青年项目、河南省高等学校重点科研项目（青年项目）；在Environmental Science & Technology, Science Bulletin, Food Chemistry等期刊发表了论文11余篇，完成国家标准1项。

教育工作经历

工作经历：

2025.12-至今，郑州大学，公共卫生学院，副研究员

教育经历：

2020.09-2025.01，江南大学，食品科学与工程，博士

2017.09-2020.06，中国农业科学院农产品加工研究所，食品加工与安全，硕士

2013.09-2017.06，青岛农业大学，食品科学与工程，本科

学术荣誉/兼职

中国毒理学会肠道毒理专业委员会委员

主持科研项目

[1] 国家自然科学基金青年科学基金，42607768，手性6PPD及其氧化产物6PPD-Q致MASLD的对映选择性毒性机制研究，2027-01至2029-12，主持。

[2] 河南省高等学校重点科研项目（青年项目），27AQ330002，手性6PPD-Q致DKD发病的对映选择性毒性机制研究，2027-01至2028-12，主持。

代表性成果

论文：

[1] Jia Zhang, Aihong Wu, Lingling Guo, Xiaoling Wu, Chuanlai Xu, Hua Kuang, Xinxin Xu*. Nonalcoholic fatty liver disease development in male mice upon exposure to flubendiamide. Environmental Science & Technology 2024, 58, (6), 2672-2682.

[2] Jia Zhang, Xinxin Xu, Hua Kuang, Chuanlai Xu, Xiaoling Wu*. Potential health risk analysis of chlorantraniliprole in vivo. Science Bulletin 2023, 68, (22), 2712-2716.

[3] Jia Zhang, Shuang Zhang, Xinxin Xu, Hua Kuang, Chuanlai Xu, Xiaoling Wu*. Tween 80 exposure induces colitis by disrupting intestinal tryptophan metabolism. Environmental Science & Technology 2026, 60, (1), 311-323.

[4] Jia Zhang, Renzhi Huang, Yongwei Feng, Ting Yang, Maozhong Sun, Hua Kuang, Chuanlai Xu, Lingling Guo*. Development and validation of stable isotope dilution LC–MS/MS method for simultaneous quantification of four Alternaria toxins in 15 food commodities. Food Chemistry 2024, 457, 140122.

[5] Jia Zhang#, Minmin Li#, Zhiqiang Kong, Tiecheng Bai, Rui Quan, Tengfei Gao, Lifang Duan, Yongguo Liu, Bei Fan*, Fengzhong Wang*. Model prediction of herbicide residues in soybean oil: Relationship between physicochemical properties and processing factors. Food Chemistry 2022, 370, 131363.

[6] Jia Zhang#, Min-Min Li#, Rui Zhang, Nuo Jin, Rui Quan, De-Yong Chen, Frédéric Francis, Feng-Zhong Wang*, Zhi-Qiang Kong*, Bei Fan*. Effect of processing on herbicide residues and metabolite formation during traditional Chinese tofu production. LWT-Food Science and Technology 2020, 131, 109707.

[7] Jia Zhang, Liwei Xu, Xinxin Xu, Xiaoling Wu*, Hua Kuang, Chuanlai Xu*. Development, optimization and validation of modified QuEChERS based UPLC-MS/MS for simultaneous determination of nine steroid hormones in milk powder and milk. New Journal of Chemistry 2022, 46, (30), 14597-14604.

[8] Jia Zhang, Liwei Xu, Xinxin Xu, Xiaoling Wu,*, Hua Kuang and Chuanlai Xu*. Profiles of sterigmatocystin and its metabolites during traditional Chinese rice wine processing. Biosensors 2022, 12, (4), 1-14.

[9] Renzhi Huang, Jia Zhang, Xinxin Xu, Maozhong Sun, Liguang Xu, Hua Kuang, Chuanlai Xu, Lingling Guo. The multiple benefits of bioactive polysaccharides: From the gut to overall health. Trends in Food Science & Technology 2024, 152, 104277.

[10] Renzhi Huang, Jia Zhang, Maozhong Sun, Liguang Xu, Hua Kuang, Chuanlai Xu, Lingling Guo. Oat β-glucan enhances gut barrier function and maintains intestinal homeostasis in naturally aging mice. International Journal of Biological Macromolecules 2025, 305, 141129.

[11] Xiao Guo, Chen Li, Jia Zhang, Maozhong Sun, Jun Xu, Chuanlai Xu, Hua Kuang, Liguang Xu. Chiral nanoparticle-remodeled gut microbiota alleviates neurodegeneration via the gut–brain axis. Nature Aging 2023, 3, 1415–1429.

国家标准：

[1] 张嘉（3/5）；GB 5009.310-2026《食品安全国家标准 食品中交链孢毒素的测定》