基本介绍

卢洁，女，1969年生，博士，教授。加拿大York University访问学者。研究方向为卫生服务统计方法与应用，临床试验设计与评价、慢性非传染性疾病防治及分子生物学。主持省部共建项目2项，省科技攻关等项目4项；主持药物上市后安全性评价等横向项目7项，参与国家基金项目、国家“十二五”、“十三五”等专项课题 6项。发表论文60余篇，其中SCI收录40余篇。获得省科技进步二等奖1项、三等奖1项，计算机软件著作权登记1项；省教育教学科学成果奖等2项，校教育教学成果奖4项。

教育工作经历

工作经历：

[1]2021-至今，郑州大学，公共卫生学院，教授

[2]2017-2018，加拿大 York University, 访问学者

[3]2007-2020，郑州大学，公共卫生学院，副教授

[4]1993-2004，开封市医学科学研究所，副主任医师

教育经历：

[1]2004-2007，郑州大学，临床医学院 肿瘤学，博士

[2]1999-2003，郑州大学，临床医学院 神经内科，硕士

[3]1988-1993，河南南医科大学, 预防医学, 本科

学术荣誉/兼职

[1]河南省卒中学术委员会；常务委员

[2]中华医学会临床流行病学和循证医学分会方法学组；委员

[3]国家医疗保障医药管理司的疾病诊断相关分级组（DRG）的河南组专家

[4]河南省药学会药物警戒专业委员会；委员

[5]河南省医学传播学会；理事

主持科研项目

[1]河南省药品评价中心，横向项目（编号：20230134A；起止年限：2023-2025）：河南省医疗器械不良事件监测工作站评价项目，主持.

[2]河南省自然科学基金面上项目（基础前沿）（编号：212300410402，起止年限：2021-2022，编码 lncRNAs的甲基化基因与儿童白血病预后的关联研究，主持.

[3]北京中生恒益医药科技有限公司河南分公司，横向项目（编号：20210820A；起止年限：2021-2022）：四价流感病毒裂解疫苗Ⅰ期临床试验，主持.

[4]北京中生恒益医药科技有限公司河南分公司，横向项目（编号：20200366A；起止年限：2020-2021）：mRNA新型冠状病毒肺炎疫苗I/II期临床试验，主持.

[5]北京中生恒益医药科技有限公司河南分公司，横向项目（编号：20200480A；起止年限：2020-2021）：新冠疫苗人群中接种的批间一致性及免疫桥接临床试验，主持.

[6]中国医学科学院阜外医院，横向项目（编号：20190220A；起止年限：2019-2020）：流行病学随访调查以及环境和生活方式对心血管病影响的研究，共同主持.

[7]河南省高等学校重点科研项目计划（编号：18B330003，起止年限：2018-2019）：儿童白血病DNA甲基化模式研究及风险判别模型构建，主持.

[8]河南省科技厅科技攻关计划项目（编号：172102310194，起止年限：2017-2018）：基于生物信息学分析的基因DNA甲基化与儿童白血病易感性的关联研究，主持.

[9]国家卫生和计划生育委员会科研基金项目/河南省医学科技攻关计划省部共建项目（编号：201301001，起止年限：2014-2016）：河南省白血病发病环境、遗传危险因素及高危预警模型研究，主持.

[10]河南省食品药品评价中心，横向项目（起止年限 2013-2014）：关于烟酸及类似物的有效性和安全性研究，主持.

[11]国家食品药品监督管理局药品评价中心（起止年限2011-2013）：关于托哌酮、曲美他嗪的安全性和有效性研究，主持.

论文

[1]Shuaijie Gao, Hao Zhu, Xinyu Chang, Xiting Cao, Zhenwei Wang, Xiaoxuan Chu, Lu Zhang, Xinhua Wang, Jie Lu*. Cardiovascular death risk in patients with solid tumors: a population-based study in the United States. Eur J Cancer Prev. 2025;34(1):11.

[2]Jie Lu, Xiting Cao, Xinyu Chang, Guowei Zheng, Hao Zhu, Shuaijie Gao, Lu Zhang, Xiancan Jia, Xuezhong Shi, Yongli Yang*. Associations between physical activity and all-cause and cardiovascular mortality in adults with type 2 diabetes mellitus: A prospective cohort study from NHANES 2007-2018. Primary Care Diabetes. 2024;18(1):44.

[3]Yamin Ke, Huifang Hu, Jinli Zhang, Lijun Yuan, Tianze Li, Yifei Feng, Yuying Wu, Xueru Fu, Mengmeng Wang, Yajuan Gao, Weifeng Huo, Yaobing Chen, Wenkai Zhang, Longkang Wang, Xi Li, Jinyuan Pang, Zeqiang Zheng, Fulan Hu, Ming Zhang, Liang Sun, Yang Zhao, Jie Lu, Dongsheng Hu. Alcohol Consumption and Risk of Fractures: A Systematic Review and Dose-Response Meta-Analysis of Prospective Cohort Studies. Adv Nutr. 2023;14(4):599.

[4]Jie Lu, Xinyu Chang, Guowei Zheng, Xiting Cao, Zhenwei Wang, Hao Zhu, Shuaijie Gao, Yuanlin Xi*. A novel signature identified by pyroptosis-related lncRNAs clusters predicts prognosis and tumor immune microenvironment for pediatric acute myeloid leukemia. GPD. 2023;2(1):230.

[4]Jie Lu, Guowei Zheng, Ani Dong, Xinyu Chang, Xiting Cao, Mengying Liu, Xuezhong Shi, Chunmei Wang, Yongli Yang, Xiaocan Jia*. Prognostic characteristics of immune subtypes associated with acute myeloid leukemia and their identification in cell subsets based on single-cell sequencing analysis. Front Cell Dev Biol. 2022;23(10):990034.

[6]Guowei zheng, Mengying Liu, Xinyu Chang, Xiting Cao, Ani Dong, Huili Zhu, Wanli Hu, Junna Xie, Yang Zhao, Dongsheng Hu, Xiaocan Jia, Yongli Yang, Xuezhong Shi, Jie Lu*. Comprehensive analysis of N6-methyladenosine-related long noncoding RNA prognosis of acute myeloid leukemia and immune cell infiltration. Front Genet. 2022;4(13):888173.

[7]Mengying Liu, Guowei Zheng, Xiting Cao, Xinyu Chang, Ningning Zhang, Ge Liang, Anran Wang, Yan Yu, Yongli Yang, Yang Zhao, Xuezhong Shi, Dongsheng Hu, Jie Lu*. Better medications adherence lowers cardiovascular events, stroke, and all-cause mortality risk: A dose-response meta-analysis. J Cardiovasc Dev Dis. 2021;2;8(11):146.

[8]Ranran Qie, Leilei Liu, Dongdong Zhang, Minghui Han, Bingyuan Wang, Yang Zhao, Dechen Liu, Chunmei Guo, Quanman Li, Qionggui Zhou, Gang Tian, Shengbing Huang, Xiaoyan Wu, Pei Qin, Jianxin Li, Jie Cao, Ming Zhang, Jianfeng Huang, Jie Lu*, Dongsheng Hu*. Dose-Response Association Between High-Density Lipoprotein Cholesterol and Stroke: A Systematic Review and Meta-Analysis of Prospective Cohort Studies. Prev Chronic Dis 2021;18:E45.

[9]Ningning Zhang, Ge Liang, Mengying Liu, Guowei Zheng, Hailan Yu, Yage Shi Yihe Zhang, Hao Wang, Yapeng Li, Yuming Xu, Jie Lu*. Metabolically healthy obesity increases the prevalence of stroke in adults aged 40 years or older: Result from the China National Stroke Screening survey. Preventive Medicine. 2021;48:106551.

[10]Quanman Li, Yu Liu, Xizhuo Sun, Honghui Li, Cheng Cheng, Leilei Liu, Feiyan Liu, Qionggui Zhou, Chunmei Guo, Gang Tian, Ranran Qie, Minghui Han, Shengbing Huang, Linlin Li, Bingyuan Wang, Yang Zhao, Yongcheng Ren Ming Zhang, Dongsheng Hu, Jian Wu, Jie Lu. Dose-response association between adult height and all-cause mortality: a systematic review and meta-analysis of cohort studies. Eur J Public Health. 2021; 31(3):652.

[11]Ranran Qie, Minghui Han, Shengbing Huang, Quanman Li, Leilei Liu, Dongdong Zhang, Cheng Cheng, Yang Zhao, Dechen Liu, Pei Qin, Chunmei Guo, Qionggui Zhou, Gang Tian, Yanyan Zhang, Xiaoyan Wu, Yuying Wu, Yang Li, Xingjin Yang, Yang Zhao, Yifei Feng, Fulan Hu, Ming Zhang, Dongsheng Hu, Jie Lu. Association of TCF7L2 gene polymorphisms, methylation, and gene-environment interaction with type 2 diabetes mellitus risk: A nested case-control study in the Rural Chinese Cohort Study. J Diabetes Complications. 2021;35(3):107829.

[12]Dechen Liu, Pei Qin, Leilei Liu, Yu Liu, Xizhuo Sun, Honghui Li, Yang Zhao, Qionggui Zhou, Quanman Li, Chunmei Guo, Gang Tian, Xiaoyan Wu, Minghui Han, Ranran Qie, Shengbing Huang, Ming Zhang, Dongsheng Hu*, Jie Lu*. Association of pulse pressure with all-cause and cause-specific mortality. J Hum Hypertens. 2021; 35(3):274.

[13]Dechen Liu, Pei Qin 2, Yu Liu, Xizhuo Sun, Honghui Li, Xiaoyan Wu, Yanyan Zhang, Minghui Han, Ranran Qie, Shengbing Huang, Yang Li, Yuying Wu, Xingjin Yang, Yifei Feng, Yang Zhao, Ming Zhang, Dongsheng Hu, Jie Lu*. Sex-specific association of resting heart rate with type 2 diabetes mellitus, J Diabetes Complications. 2020;34(12):107754.

[14]Dechen Liu, Li Guan, Yang Zhao, Yu Liu, Xizhuo Sun, Honghui Li, Zhaoxia Yin, Linlin Li, Yongcheng Ren1, Bingyuan Wang, Cheng Cheng, Leilei Liu1, Xu Chen1, Qionggui Zhou3, Quanman Li1, Chunmei Guo1, Gang Tian1, Ming Zhang, Dongsheng Hu, Jie Lu*. Association of triglycerides to high-density lipoprotein-cholesterol ratio with risk of incident hypertension. Hypertens Res. 2020; 43(9):948.

[15]Minghui Han, Quanman Li, Ranran Qie, Chunmei Guo, Qionggui Zhou, Gang Tian a, Shengbing Huang, Xiaoyan Wu, Yongcheng Ren, Yang Zhao, Dechen Liu, Dongdong Zhang, Leilei Liu, Feiyan Liu, Xu Chen, Cheng Cheng, Yang Li, Xingjin Yang, Yang Zhao, Yifei Feng, Yu Liu, Honghui Li, Xizhuo Sun, Pei Qin, Qing Chen, Ming Zhang, Dongsheng Hu, Jie Lu*. Association of non-HDL-C/HDL-C ratio and its dynamic changes with incident type 2 diabetes mellitus: The Rural Chinese Cohort Study. J Diabetes Complications. 2020;34(12):107712.

[16]Quanman Li, Ranran Qie, Pei Qin, Dongdong Zhang, Chunmei Guo, Qionggui Zhou, Gang Tian, Dechen Liu, Xu Chen, Leilei Liu, Feiyan Liu, Cheng Cheng, Minghui Han, Shengbing Huang, Xiaoyan Wu, Yang Zhao, Yongcheng Ren, Ming Zhang, Dongsheng Hu, Jie Lu*. Association of weight-adjusted-waist index with incident hypertension: The Rural Chinese Cohort Study. Nutrition, Nutr Metab Cardiovasc Dis. 2020;30(10):1732.

[17]Minghui Han, Li Guan, Yongcheng Ren, Yang Zhao, Dechen Liu, Dongdong Zhang, Leilei Liu, Feiyan Liu, Xu Chen, Cheng Cheng, Quanman Li, Chunmei Guo, Qionggui Zhou, Gang Tian, Ranran Qie, Shengbing Huang, Xiaoyan Wu, Yu Liu, Honghui Li, Xizhuo Sun, Ming Zhang, Dongsheng Hu, Jie Lu*. Dietary iron intake and risk of death due to cardiovascular diseases: a systematic review and dose–response meta-analysis of prospective cohort studies. Asia Pac J Clin Nutr. 2020;29(2):309.

[18]Chunmei Guo, Pei Qin, Quanman Li, Dongdong Zhang, Gang Tian, Dechen Liu, Leilei Liu, Cheng Cheng, Xu Chen, Ranran Qie, Minghui Han, Shengbing Huang, Qionggui Zhou, Feiyan Liu, Xiaoyan Wu, Yang Zhao, Yongcheng Ren, Yu Liu, Xizhuo Sun, Honghui Li, Bingyuan Wang, Ming Zhang, Jie Lu∗, Dongsheng Hu*. Association between mean arterial pressure and risk of type 2 diabetes mellitus: The Rural Chinese Cohort Study. Prim Care Diabetes. 202014(5):448.

[19]Dechen Liu, Yang Zhao, Yu Liu, Xizhuo Sun, Honghui Li, Zhaoxia Yin, Linlin Li, Bingyuan Wang, Yongcheng Ren, Cheng Cheng, Leilei Liu, Xu Chen, Feiyan Liu, Qionggui Zhou, Gang Tian, Quanman Li, Chunmei Guo, Xiaoyan Wu, Minghui Han, Ranran Qie, Shengbing Huang, Ming Zhang, Dongsheng Hu*,Jie Lu*. Adiposity and insulin resistance as mediators between age at menarche and type 2 diabetes mellitus; Menopause. 2020;27(5):579.

[20]Yiran Wang, Pan Gao, Ge Liang, Ningning Zhang, Chunmei Wang, Yingchao Wang, Luting Nie, Xuewei Lv, Wenjing Li, Qianqian Guo, Xiaowen Jiang, Jie Lu*. Maternal prenatal exposure to environmental factors and risk of childhood acute lymphocytic leukemia: A hospital-based case-control study in China, Cancer Epidemiol. 2019;58,pp.146.

著作

[1]卢洁，副主编. SPSS医学数据分析教程（卫生统计学实习指导）, 郑州大学出版社.  2023年.

[2]卢洁，副主编. 中国高校医学期刊论文统计报告推荐清单（2023版）, 2023年.

专利/奖励

[1]卢洁(1/4)，计算机软件著作权登记，医院感染风险预防管理系统V1.0，2024.

[2]卢洁(3/9)，急性单核细胞白血病THP-1细胞系白血病干细胞的分选、鉴定及靶向治疗的研究, 河南省卫生与计划生育委员会，河南省医学科学技术进步奖，二等奖，2017.

[3]卢洁(1/7)，髓细胞白血病FLT3信号传导NFκB、SMRT作用及抑制策，河南省人民政府， 河南省科技进步奖，三等奖，2015.

[4]卢洁(5/10)，艾滋病综合防治居民健康档案信息管理平台设计与应用, 河南省人民政府, 河南省科技进步奖，二等奖，2014.

[5]卢洁(2/11)，人PTEN基因RNAi和RESC慢病毒载体的构建及其功能的相关性研究, 河南省卫生与计划生育委员会, 河南省医学科技进步奖, 一等奖，2015.