王 佳

讲师、硕士生导师

研究方向：卫生检验

联系电话：0371-67781927

邮箱：wangjia@zzu.edu.cn

1.基本信息

王佳，女，1983年出生，博士学历，讲师，硕士研究生导师。主要研究方向为：色谱质谱联用技术在食品安全、环境分析中的应用研究；基于色谱质谱联用技术平台的代谢分析技术（代谢组学和脂质组学）在慢性非传染性疾病生物标志物的筛选领域的应用。

2.教育经历

2009-09至2015-07，郑州大学，化学学院，博士，导师: 唐孝炎

2006-09至2009-07，郑州大学，化学学院，硕士，导师: 张瑞芹

2002-09至2006-07，郑州大学，化学学院，本科

3.科研与学术工作经历

2016-08至今, 郑州大学, 公共卫生学院, 讲师4.

4.主持或参加科研项目（课题）情况（按时间倒序排序）:

（1）国家自然科学基金委员会，面上项目，42277430，全球变暖对“胎儿-童年-成年”代谢性疾病影响毒理学与干预研究，2023-01-01 至 2026-12-31，54万元，在研，参与

（2）国家自然科学基金委员会，青年项目，21607136，围产期双酚S暴露致胰岛β细胞损伤的IGF2/H19表观遗传学机制研究，2017-01至2019-12，20万元，已结项，参与

（3）河南省教育厅，河南省自然科学基金青年项目，222300420305，基于代谢组学的大气细颗粒物暴露致糖脂代谢异常与炎症反应关系研究，2022-01至2023-12，5万元，在研，主持

5.个人研究领域

质谱分析：色谱质谱联用分析技术在营养、食品卫生和环境分析领域的应用。基于高分辨质谱的性能与特点，进行食品中非法添加剂、药物残留及环境样品中污染物等筛查。

代谢组学：利用液质联用技术对分子量1500以下的小分子代谢物进行定性和定量分析，目前学院拥有Waters TQD和Waters UPLC/UPCC VION IMS- QTOF MS质谱仪，主要进行非靶向/靶向代谢组学分析和脂质组学分析，及基于质谱的化合物结构鉴定。

6.代表性研究成果

6.1 代表性期刊论文

(1) Lei Yan; Pei Han; Jin Man; Yongmei Tian; Fudi Wang*; Jia Wang*; Discovery of lipid profiles of type 2 diabetes associated with hyperlipidemia using untargeted UPLC Q-TOF/MS-based lipidomics approach, Clinica Chimica Acta, 2021, 520: 53-62

(2) Yuhang, Jiang; Cuifeng, Li; Qian, Wu; Peng, An; Laiquan, Huang; Jia,Wang; Chen, Chen; Xi, Chen; Fan, Zhang; Li, Ma; Sanhong, Liu; Hanqing, He; Shuyun, Xie; Yangbai, Sun; Hanshao, Liu; Yu, Zhan; Yu, Tao; Zhi, Liu; Xiaohua, Sun; Yiming, Hu; Qi, Wang; Deji, Ye; Jie, Zhan; Shanhua, Zou; Yangzihan, Wang; Gang, Wei; Yongzhong, Liu; Yufang, Shi; Y.Eugene, Chin; Yongqiang, Hao; Fudi, Wang*; Xiaoren, Zhang*.Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses, Nature Communications, 2019, 10: 2935

(3) Yongjuan Xin#; Hong Gao#; Jia Wang#; Yuzhen Qiang; Mustapha Umar Imam; Yang Li; Jianyao Wang; Ruochen Zhang; Huizhen Zhang; Yingying Yu; Hao Wang; Haiyang Luo; Changhe Shi; Yuming Xu; Shintaro Hojyo; Toshiyuki Fukada; Junxia Min; Fudi Wang*; Manganese transporter Slc39a14 deficiency revealed its key role in maintaining manganese homeostasis in mice, Cell Discovery, 2017, 3: 17025

(4) Zhidan, Xia#; Jiayu, Wei#; Yingniang, Li; Jia, Wang; Wenwen, Li; Kai, Wang; Xiaoli, Hong; Lu, Zhao; Caiyong, Chen; Junxia, Min*; Fudi, Wang*; Zebrafish slc30a10 deficiency revealed a novel compensatory mechanism of Atp2c1 in maintaining manganese homeostasis, PLoS Genetics, 2017, 13:1006892

(5) Zhen, Yan; Jia, Wang; Juan, Li; Nan, Jiang; Ruiqin, Zhang; Weichao, Yang; Yao, Wu; Weidong, Wu*; Oxidative Stress and Endocytosis are Involved in Upregulation of Interleukin-8 Expression in Airway Cells Exposed to PM2.5, Environmental Toxicology, 2016, 31: 1869-1878

(6) Jia Wang; Xiao Li; Wenkai Zhang; Nan Jiang; Ruiqin Zhang; Xiaoyan Tang* ; Secondary PM2.5 in Zhengzhou, China: Chemical species based on three years of observations, Aerosol and Air Quality Research, 2016, 16: 91-104

(7) Jia Wang; Xiao Li; Nan Jiang; Wenkai Zhang; Ruiqin Zhang; Xiaoyan Tang* ; Long term observations of PM2.5-associated PAHs: Comparisons between normal and episode days, Atmospheric Environment, 2015, 104: 228-236

(8) Jia Wang; Ningbo Geng; Yifei Xu; Wending Zhang; Xiaoyan Tang; Ruiqin Zhang* ; PAHs in PM2.5 in Zhengzhou: concentration, carcinogenic risk analysis, and source apportionment, Environmental Monitoring and Assessment, 2014, 186: 7461-7473

(9) Ningbo, Geng; Jia, Wang, ; Yifei, Xu; Wending, Zhang; Chun, Chen; Ruiqin, Zhang*; PM2.5 in an industrial district of Zhengzhou, China: Chemical composition and source apportionment, Particuology, 2013, 11: 99-109

6.2 著作

(1) 王佳 参编. 食品中有害物质快速分析选论（第七章），郑州大学出版社，556千字，2019.

(2) 王佳 参编. 卫生化学实验, 郑州大学出版社, 2020.