于斐
博士，副教授、硕士生导师、
研究方向：食品卫生检验、生物分子识别和检测，主要从事食品中营养物质、有害物质等高通量检测和风险评估；疾病生物标志物识别与检测。
联系电话：13783605498
邮箱：yufei@zzu.edu.cn
一、基本介绍
于斐，女，1977年出生，公共卫生学院副教授、硕士生导师。郑大大学青年骨干教师， 郑州大学“三育人”先进个人；主持河南省教学研究示范课程项目，主持郑州大学 “课程思政”教育教学改革试点课程重点项目。获得河南省自然科学优秀学术论文二等奖5项。获得河南省教育厅科技进步二等奖1项；兼任河南省预防医学会卫生检测检验专业委员会委员，河南省营养学会会员。
二、教育/工作经历
工作经历：
[1] 2019-2020，Washington State University，Voiland School of Chemical Engineering & Bioengineering 访问学者
[2] 2017-至今， 郑州大学，公共卫生学院，副教授
[3] 2007-2016，郑州大学， 公共卫生学院，讲师
[4] 2004-2006，郑州大学，公共卫生学院，助教
教育经历：
[1] 2012-2016，郑州大学，公共卫生学院流行病与卫生统计学专业，博士
[2] 2001-2004，郑州大学，郑州大学化学系分析化学专业，硕士
[3] 1997-2001，郑州大学，郑州大学化学系精细化工专业，本科
四、主持科研项目
[1] 国家自然科学基金青年基金项目（编号：81402721；年限：2014-2017）：新型磁蛋白纳米微粒标记技术的化学发光酶联免疫法检测血清中DNA甲基化转移酶1。
[2] 河南省科技重点研发与推广项目（科技攻关）项目（编号：202102310140；年限：2020-2021）：重要肺癌标志物—DNA甲基化关键酶DNMT1活性与水平同步检测方法的构建及应用研究。
[3] 河南省教育厅科学技术研究重点项目（编号：14A330008，年限：2014-2016），一种新型的磁酶免疫增强化学发光分析技术研究。
[4] 郑州大学青年教师基础研究培育基金（编号：JC21838047，年限：2020-2021），基于自组装核酸探针信号放大及免疫杂交技术同步检测DNA甲基化转移酶1水平和活性体系的构建及应用研究。
五、代表性成果
l 论文
[1] Lulu Song, Tiantian Ma, Fangfang Gong, Leiliang He, Yilin Wang, Qiongwen Zhang, Shuying Zhang, Yongjun Wu, Li-e Liu, Fei Yu*. A high sensitivity strategy of DNMT1 activity detection based on self-assembled nucleic acid probe signal amplification technique. Sensors and Actuators B: Chemical,2023, 385: 133610.
[2] Mimi Zhang, Fei Yu*, Yuan Xue, Lulu Song, Mengsi Du, Xing Li * and Wenjie Li. The Relationship of 25(OH)D3 with Diabetes Mellitus and the Mediation Effect of Lipid Profile in Chinese Rural Population of Henan Province. Medicina Lithunaia. 2022, 58(1): 85.
[3] Zhenzhen Wan, Fangfang Gong, Mimi Zhang, Leiliang He, Yilin Wang, Songcheng Yu, Jie Liu, Yuming Wu, Li’e Liu, Yongjun Wu, Lingbo Qu , Jiaqi Sun, Fei Yu*. Detection of the level of DNMT1 based on self-assembled probe signal amplification technique in plasma. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy，2021, 261:120020.
[4] He ST, He LL, Liu BB, Yu SC, Liu L, Tian YM, Wang J, Ding LH, Wang YL, Qu LB, Yu F*, Wu YJ*. Development of a rapid and sensitivity magnetic chemiluminescence immunoassay for DNA methyltransferase 1 in human serum. CHINESE CHEMICAL LETTERS, 2019, 30(5):1031-1034.
[5] Fei Yu, Yamin Xiong, Songcheng Yu, Leiliang He, Shanshan Niu, Yuming Wu, Jie Liu, Lingbo Qu, Li-e Liu, Yong-jun Wu. Magnetic immunoassay using CdSe/ZnS quantum dots as fluorescent probes to detect the level of DNA methyltransferase 1 in human serum sample. International Journal of Nanomedicine. 2018, 13: 429–437.
[6] Fei Yu, ChongJian Wang, Ling Wang, HongLin Jiang, Yue Ba, LingLing Cui, Yan Wang, SongCheng Yu and WenJie Li. Study and evaluation the impact of VDR variants on the risk of T2DM in Han Chinese. Journal of Diabetes. 2017, 9(3): 275–284.
[7] Fei Yu, Lingling Cui, Xing Li, et al. The genetic polymorphisms in vitamin D receptor and the risk of type 2 diabetes mellitus: an updated meta-analysis. Asia pacific Journal of Clinical Nutrition. 2016, 25(3): 614-624.
[8] Fei Yu, Songcheng Yu, Lanlan Yu，et al. Determination of residual enrofloxacin in food samples by a sensitive method of chemiluminescence enzyme immunoassay. 2014, Food Chemistry, 149: 71-75.
[9] Fei Yu，Yongjun Wu, Songcheng Yu, et al. A competitive chemiluminescence enzyme immunoassay for rapid and sensitive determination of enrofloxacin. 2012, Spectrochimica Acta Part A, 93: 164-168.
[10] Songcheng Yu, Fei Yu, Yaping Li, et al. Magnetic nanoparticles replacing microplate as immobile phase could greatly improve the sensitivity of chemiluminescence enzymatic immunoassay for deoxynivalenol. 2016, Food Control. 60: 500-504.
[11] Songcheng Yu, Fei Yu, Hongquan Zhang, et al. Optimization of condition for conjugation of enrofloxacin to enzymes in chemiluminescence enzyme immunoassay. Spectrochimica Acta Part A, 2014, 93: 47-51.
[12] Liang Yan-li, Yu Fei, YuSong-cheng , et al. Effect of the luminol signal enhancer on the chemiluminescence intensity and kinetics. 2012, Journal of Luminescence, 132: 1021–1024.
[13] Songcheng Yu, Fei Yu, Li-e Liu, Hongquan Zhang, Zhenzhong Zhang, Lingbo Qu and Yongjun Wu. Which one of the two common reporter systems is more suitable for chemiluminescent enzyme immunoassay: alkaline phosphatase or horseradish peroxidase? Luminescence, 2015, 31(3): 888-892.
[14] Li-E Liu, Fei Yu, Jindun Liu, Xiuli Han, Haoqin Zhang and Bing Zhang. Removal of Auramine O from Aqueous Solution Using Sesame Leaf: Adsorption Isotherm and Kinetic Studies. Asian Journal of Chemistry, 2013, 25(4): 1991-1998.
[15] Yan Wang, Fei Yu, Songcheng Yu, Dongdong Zhang, Jun Wang, Han Han, Hualei Sun,Yuan Xue, Yue Ba, Chongjian Wang, Wenjie Li. Triangular relationship between CYP2R1 gene polymorphism, serum25(OH)D3 levels and T2DM in a Chinese rural population. Gene. 2018: 678:172-176.
