施学忠

二级教授、博士研究生导师、流行病与卫生统计学学科负责人

研究方向：卫生服务统计方法与应用；临床试验设计与评价

邮箱：xzshi@zzu.edu.cn

一、基本介绍

施学忠，男，博士，二级教授，博士研究生导师，流行病与卫生统计学学科负责人。1985年获得原河南医科大学医学学士学位，1991年获得原同济医科大学医学硕士学位，2008年获得郑州大学医学博士学位。2015年8月至2016年8月在美国Tulane University公共卫生与热带医学学院生物统计与生物信息学系访学交流。在复杂疾病统计建模和艾滋病综合防治领域有较深入研究。主持国家自然科学基金面上项目和国家科技重大专项课题4项；河南省科技攻关计划项目、省自然科学基金项目和临床试验等项目25项。获得河南省科技进步二等奖3项，国家发明专利3项，计算机软件著作权登记1项，编写著作18部，发表中文核心及SCI论文200余篇。

二、教育/工作经历

l 工作经历

[1]. 2009.05-至今，郑州大学，学报编辑部

[2]. 2003.04-至今，郑州大学，公共卫生学院，教授（二级）

[3]. 1996.09-2003.04，郑州大学，公共卫生学院，副教授

[4]. 1985.07-1996.09，河南医科大学，预防医学系，助教，讲师

l 教育经历

[1]. 2015.08-2016.08，美国杜兰大学，生物统计学系，访问学者

[2]. 2005.09-2009.12，郑州大学，流行病与卫生统计学专业，博士

[3]. 1988.09-1991.07，河南医科大学、同济医科大学，卫生统计学，硕士

[4]. 1980.09-1985.07，河南医科大学，预防医学，学士

三、学术荣誉/学术兼职

l 学术荣誉

[1]. 2019年河南省高层次人才

[2]. 2009年河南省教育系统教学技能二等奖

[3]. 2006年河南省教育厅学术技术带头人

l 学术兼职

[1]. 河南省医学传播学会 会长

[2]. 中国高校科技期刊研究会医学期刊专委会 副主任委员

[3]. 中国医药教育协会医药统计专业委会会 常务委员

[4]. 中国卫生信息学会卫生统计理论与方法委员会 常务委员

四、主持科研项目

[1]. 2020年国家自然科学基金：基于多元统计建模的代谢综合征遗传易感性和生物机制研究（项目编号：82073670）.起止时间：2021-2024. 主持.

[2]. 国家“十三五”科技重大专项子课题：普通人群HIV新发感染监测队列研究（项目编号：2018ZX10715009）.起止时间：2018-2020. 主持.

[3]. 国家“十二五”科技重大专项子课题：河南省防治艾滋病规模化现场流行病学和干预研究（项目编号：2012ZX10004905）.起止时间：2012-2016. 主持.

[4]. 国家“十一五”科技重大专项子课题：艾滋病综合防治研究现场组织建设与新型电子健康档案和信息资源中心构建（项目编号：2009ZX10001）.起止时间：2009-2012. 主持.

[5]. 横向项目：水痘减毒活疫苗扩大使用人群临床试验（项目编号：20210683A）.起止时间：2021-2024. 主持.

[6]. 横向项目：百白破和重组肺炎球菌蛋白疫苗临床试验（项目编号：20190519A）.起止时间：2019-2024. 主持.

五、代表性成果

l 论文

[1] Xuezhong Shi, Ani Dong, Yongli Yang, Guowei Zheng, Nana Wang, Chaojun Yang, Yuping Wang1, Jie Lu, Xiaocan Jia*. Integrated analysis of single‑cell and bulk RNA‑sequencing identifies a signature based on T‑cell marker genes to predict prognosis and immunotherapy response in bladder cancer. Journal of Cancer Research and Clinical Oncology.2023. (IF=8.787，中科院2区).

[2] Yali Niu, Xiaocan Jia, Nana Wang, Mengyang Yuan, Ani Dong, Yongli Yang, Xuezhong Shi*. Identification of exosomesrelated lncRNAs in clear cell renal cell carcinoma based on Bayesian spikeandslab lasso approach. Functional & Integrative Genomics. 2023. (IF=3.674，中科院3区)

[3] Xuezhong Shi, Mengyang Yuan, Yongli Yang, Nana Wang, Yali Niu, Chaojun Yang, Ani Dong, Huili Zhu, Xiaocan Jia*. Prognostic Model for Clear-cell Renal Cell Carcinoma Based on Natural Killer Cell-related Genes. 2022. (IF=3.121，中科院3区)

[4] Chaojun Yang, Xiaocan Jia, Yuping Wang, Jingwen Fan, Chenyu Zhao, Yongli Yang*, Xuezhong Shi*. Association between Dietary Total Antioxidant Capacity of Antioxidant Vitamins and the Risk of Stroke among US Adults. Antioxidants (Basel). 2022. (IF=7.675, 中科院2区)

[5] Chaojun Yang, Xiaocan Jia, Yuping Wang, Jingwen Fan, Chenyu Zhao, Yongli Yang*, Xuezhong Shi*. Trends and influence factors in the prevalence, intervention, and control of metabolic syndrome among US adults, 1999-2018. BMC Geriatr. 2022. (IF=3.913, 中科院3区)

[6] Nana Wang, Abiyasi Nanding, Xiaocan Jia, Yuping Wang, Chaojun Yang, Jingwen Fan, Ani Dong, Guowei Zheng，Jiaxin Ma, Xuezhong Shi* and Yongli Yang*.Mining of immunological and prognostic-related biomarker for cervical cancer based on immune cell signatures. Front. Immunol. 2022 (IF=8.786, 中科院2区)

[7] Xuezhong Shi, Ani Dong, Xiaocan Jia, Guowei Zheng, Nana Wang, Yuping Wang, Chaojun Yang, Jie Lu and Yongli Yang*. Integrated analysis of single-cell and bulk RNA-sequencing identifies a signature based on T-cell marker genes to predict prognosis and therapeutic response in lung squamous cell carcinoma. Front. Immunol. 2022. (IF=8.786, 中科院2区)

[8] Xuezhong Shi, Zhijuan Song, Yongli Yang, Junzhe Bao, Huili Zhu, Zixiao Luo, Yuping Wang, Meina Wu, and Xiaocan Jia*. Association and Prediction of Influenza-like Illness with Meteorological Factors in Mississippi, USA. Biomed Environ Sci. 2022. (IF=2.831, 中科院2区)

[9] Yuping Wang, Yongli Yang, Xiaocan Jia, Chenyu Zhao, Chaojun Yang, Jingwen Fan, Meina Wu, Mengdie Yu, Ani Dong, Nana Wang, Jiao Lian, Xuezhong Shi*. Identifying pleiotropic genes for major psychiatric disorders with GWAS summary statistics using multivariate adaptive association tests. Journal of Psychiatric Research. 2022. (IF=5.250，中科院2区)

[10] Xuezhong Shi, Yali Niu, Yongli Yang, Nana Wang, Mengyang Yuan, Chaojun Yang, Ani Dong, Huili Zhu, Xiaocan Jia*. Identification of a prognostic model based on immune cells signatures in clear cell renal cell carcinom. Oxid. Med. Cell. Longev. 2022. (IF=7.310，中科院2区)

[11] Yuping Wang, Jiebing Tan, Wei Wang, Xiaoran Duan, Brooke Lappe, Liuhua Shi, Yongli Yang and Xuezhong Shi*. The Association Between Polymorphisms in Cell-Cycle Genes and Mitochondrial DNA Copy Number in Coke Oven Workers. Front Public Health. 2022. (IF=6.461，中科院3区)

[12] Zixiao Luo, Xiaocan Jia, Junzhe Bao, Zhijuan Song, Huili Zhu, Mengying Liu, Yongli Yang* and Xuezhong Shi*. A Combined Model of SARIMA and Prophet Models in Forecasting AIDS Incidence in Henan Province, China. Int. J. Environ. Res. Public Health 2022. (IF=3.39，中科院3区).

[13] Zhijuan Song, Xiaocan Jia, Junze Bao, Yongli Yang, Huili Zhu, Xuezhong Shi*. Spatio-Temporal Analysis of Influenza-Like Illness and Prediction of Incidence in High-Risk Regions in the United States from 2011 to 2020. Int J Environ Res Public Health. 2021. (IF=3.39，中科院3区).

[14] Junzhe Bao, Zheng Cao, Cunrui Huang, Lin Lei, Yongli Yang, Ji Peng*, Xuezhong Shi^⁎. Modification effect of urban landscape characteristics on the association between heat and stroke morbidity: A small-scale intra-urban study in Shenzhen, China. Science of the Total Environment. 2021. (IF=7.963，中科院 2区).

[15] HuiliZhu, XiaocanJia, YupingWang, ZhijuanSong, NanaWang, YongliYang* and XuezhongShi*. M6A Classification Combined With Tumor Microenvironment Immune Characteristics Analysis of Bladder Cancer. Frontiers in Oncology. 2021. (IF=6.244，中科院2区).

[16] Xiaocan Jia, Nian Shi, Yu Feng, Yifan Li, Jiebing Tan, Fei Xu, Wei Wang, Changqing Sun, Hongwen Deng, Yongli Yang* and Xuezhong Shi*. Identification of 67 Pleiotropic Genes Associated with Seven Autoimmune/Autoinflammatory Diseases Using Multivariate Statistical Analysis. Frontiers in Immunology. 2020.( IF=8.786，中科院2区)

[17] Xiaocan Jia, Zhenhua Xia, Nian Shi, Weiping Zhang, Zixiao Luo, Yongli Yang^C and Xuezhong Shi*. The factors associated with natural disease progression from HIV to AIDS in the absence of ART, a propensity score matching analysis. Epidemiology and Infection.2020.(IF=4.434，中科院3区)

[18] Yang Yongli，Zhiwei Cheng, Xiaocan Jia, Nian Shi, Zhenhua Xia, Weiping Zhang, Xuezhong Shi*. Mortality trends of bladder cancer in China from 1991 to 2015: an age-period-cohort analysis. Cancer Management and Research. 2019. (IF=3.7，中科院2区)

[19] XiaoCan Jia, YongLi Yang, YuanCheng Chen, Zhenhua Xia, Weiping Zhang, Yu Feng, Yifan Li,Jiebing Tan, Chao Xu, Qiang Zhang, Hongwen Deng, XueZhong Shi*. Multivariate analysis of genome-wide data to identify potential pleiotropic genes for type 2 diabetes, obesity and coronary artery disease using MetaCCA. International Journal of Cardiology. 2019. (IF=6.2,中科院2区).

[20] XiaoCan Jia, YongLi Yang, YuanCheng Chen, ZhiWei Cheng, Yuhui Du, Zhenhua Xia, Weiping Zhang, Chao Xu, Qiang Zhang, Xin Xia, HongWen Deng, XueZhong Shi*. Multivariate analysis of genome-wide data to identify potential pleiotropic genes for five major psychiatric disorders using MetaCCA. Journal of Affective Disorders. 2019. (IF=3.4，中科院2区).

l 著作

[1] 施学忠 副主编. SPSS医学数据分析教程（卫生统计学实习指导）. 郑州：郑州大学出版社. 2023年.

[2] 施学忠 编委. Statistical Methods for Biomedical Research. World Scientific. 2021年.

[3] 施学忠 编委. 生物医学研究的统计方法. 北京：高等教育出版社. 2019年.

[4] 施学忠 副主编. 高级医学统计学. 北京：科学出版社. 2014年.

l 成果

[1] 中国高校科技期刊研究会：中国高校科技期刊研究会医学论文统计报告专家共识. 2023年. 第1.

[2] 计算机软件著作权登记. HIV新发感染监测队列研究平台V1.0. 2021年. 第1.

[3] 河南省教育厅：河南省高等教育教学成果奖一等奖《5+3教学模式下医学统计学在培养高素质医学人才中的应用》. 2020年. 第2.

[4] 河南省科技进步二等奖：艾滋病综合防治居民健康档案信息管理平台设计与应用. 2014年. 第1.