陈帅印

副教授、博士生导师、郑州大学青年骨干教师、医学优秀青年人才

研究方向：分子流行病学、传染病流行病学、病原毒力和耐药传播进化规律、病原前沿检测技术

联系电话：0371-67781472

邮箱：sychen@zzu.edu.cn

一、基本介绍

陈帅印，医学博士，副教授，博士生导师。主要研究方向：分子流行病学和传染病流行病学，围绕病原毒力和耐药传播进化规律、重症手足口病致病机制和早期预警、幽门螺杆菌基因工程疫苗、重大传染病防控前沿技术等开展研究。主持国家自然科学基金面上项目1项，国家传染病防控科技重大专项子课题1项，主持省厅级科研项目3项，参与国家科技重大专项2项，国家自然科学基金面上项目5项。第一或通讯作者发表SCI论文41篇，获批发明专利3项，参编规划教材3部。曾获郑州大学教师教学创新大赛一等奖、河南省教育系统教学技能竞赛三等奖等。学术兼职：中华预防医学会流行病学分会青年委员，河南省医学会公共卫生分会常委兼青委会主任委员，河南省医学会临床流行病与循证医学分会青委副主委，河南省预防医学会流行病学专业委员会委员，《中华疾病控制杂志》青年编委等。

二、教育/工作经历

工作经历：

[1] 2020-至今，郑州大学，公共卫生学院，副教授

[2] 2015-2020，郑州大学，公共卫生学院，讲师

教育经历：

[1] 2010-2014，郑州大学，流行病与卫生统计学专业，博士

[2] 2007-2010，郑州大学，流行病与卫生统计学专业，硕士

[3] 2002-2007，郑州大学，预防医学，本科

三、学术荣誉/学术兼职

l 国际期刊

[1] Clinical and Molecular Epidemiology 编委

l 国内学会与学术期刊

[1] 《中华疾病控制杂志》青年编委

[2] 中华预防医学会流行病学分会青年委员

[3] 河南省医学会公共卫生分会常委兼青委会主任委员

[4] 河南省医学会临床流行病与循证医学分会青委副主任委员

[5] 河南省预防医学会流行病学专业委员会委员

四、主持科研项目

[1] 国家自然科学基金面上项目（编号：82073618；年限：2021-2024）：RNAm6A甲基化调控miRNA-628成熟在重症手足口病中的作用机制。

[2] 河南省高等学校重点科研项目计划（编号：20A330004；年限：2020-2021），肾素血管紧张素系统与重症手足口病关系及机制。

[3] 河南省高等学校重点科研项目计划（编号：18B33002；年限：2018-2019），基于CRISPR/Cas的大肠杆菌分型检测方法。

[4] 河南省科技攻关计划项目（编号：182102310401；年限：2018-2019），肾素血管紧张素系统失稳态与重症手足口病肺损伤的关系及机制。

五、代表性成果

l 论文

[1] Zhang Teng, Geng Juan, Du Yazhe, Yang Haiyan, Jin Yuefei, Chen Shuaiyin*, Duan Guangcai. A meta-analysis of immunogenicity and safety of two versus single-doses of influenza A (H1N1) vaccine in person living with HIV. Int J STD AIDS. 2023

[2] Du Yazhe, Wang Ya, Geng Juan, Long Jinzhao, Yang Haiyan, Duan Guangcai, Chen Shuaiyin*. Molecular Mechanism of Hfq-dependent sRNA1039 and sRNA1600 Regulating Antibiotic Resistance and Virulence in Shigella sonnei. Int J Antimicrob Agents. 2023 Dec 21:107070.

[3] Zhang Yu^#, Chen Shuaiyin^#, Sun Tiantian^#, Duan Guangcai, Yang Haiyan, Feng Huifen, Jiang Wenjie, Li Dong, Ji Wangquan, Zhu Peiyu, Jin Yuefei. Abundant Neutrophils-initiated Acute Myocardial Injury Following Coxsackievirus A6 Infection. J Infect Dis. 2023 Sep 21:jiad407.

[4] Xi Yanyan, Zhao Jiaxue, Zhang Jiangfeng, Jin Yuefei, Yang H, Duan Guangcai, Chen Shuaiyin*, Long Jinzhao. Analysis of the features of 105 confirmed CRISPR loci in 487 Klebsiella variicola. Lett Appl Microbiol. 2023 Sep 1;76(9):ovad108.

[5] Zhao Jiaxue, Xi Yanyan, Zhang Jiangfeng, Jin Yuefei, Yang Haiyan, Duan Guangcai, Chen Shuaiyin*, Long J. Characterization and diversity of CRISPR/Cas systems in Klebsiella oxytoca. Mol Genet Genomics. 2023 Sep 8.

[6] Chen Jingfeng^#, Chen Shuaiyin^#, Duan Guangcai, Zhang Teng, Zhao Haitao, Wu Zhuoqing, Yang Haiyan, Ding S. Epidemiological characteristics and dynamic transmissions of COVID-19 pandemics in Chinese mainland: A trajectory clustering perspective analysis. Epidemics. 2023 Sep 26;45:100719.

[7] Geng Juan, Cheng Cheng, Chen Shuaiyin*, Wang Ya, Du Yazhe, Long Jinzhao, Jin Yuefei, Yang Haiyan, Duan Guangcai. Anxiety, depression, insomnia symptoms & associated factors among young to middle-aged adults during the resurgent epidemic of COVID-19: a cross-sectional study. Psychol Health Med 2023, 28(5): 1336-1346.

[8] Hu Quanman, Gao Yanlei, Xie Yaqi, Li Dong, An Tongyan, Chen Long, Ji Wangquan, Jin Yuefei, Long Jinzhao, Yang Haiyan, Duan Guangcai, Chen Shuaiyin*. Mechanism of RNA m6 A methylation modification regulating NLRP3 inflammasome activation for hand, foot, and mouth disease progression. J Med Virol 2023, 95(7): e28939.

[9] Shen Yue, Hu Kai, Yuan Mingzhu, Duan Guangcai, Guo Y, Chen Shuaiyin*. Progress and bioapplication of CRISPR-based one-step, quantitative and multiplexed infectious disease diagnostics. J Appl Microbiol 2023, 134(3).

[10] Wang Ya, Teng Yanli, Geng Juan, Long Jinzhao, Yang Haiyan, Duan Guangcai, Chen Shuaiyin*. Involvement of RNA chaperone hfq in the regulation of antibiotic resistance and virulence in Shigella sonnei. Res Microbiol 2023, 174(5): 104047.

[11] Yue Limin, Zhang Rongguang, Chen Shuaiyin*, Duan Guangcai. Risk Score Prediction Model of Prognosis in GC Patients by Age and Gender Combined With m6A Modification Genes FTO and RBM15. Front Cell Dev Biol 2022, 10.

[12] Ding Ronghua, Shen Yue, Yuan Mingzhu, Zheng Xue, Chen Shuaiyin*, Duan Guangcai. Rapid and facile detection of HBV with CRISPR/Cas13a. New J Chem 2022, 46(41): 19997-20004.

[13] Chen Long, Hu Kai, Cheng Cheng, Hu Quanman, Zhang Liang, An Tongyan, Guo Yongjun, Chen Shuaiyin*, Duan Guangcai. Risk of adverse outcomes in inflammatory bowel disease patients infected with SARS-CoV-2: a systematic review and meta-analysis. Int J Colorectal Dis 2022, 37(11): 2277-2289.

[14] Jiang Wenjie, Ji Wangquan, Zhang Yu, Xie Yaqi, Chen Shuaiyin*, Jin Yuefei, Duan Guangcai. An Update on Detection Technologies for SARS-CoV-2 Variants of Concern. Viruses 2022, 14(11).

[15] Zheng Xue, Li Yuankun, Yuan Mingzhu, Shen Yue, Chen Shuaiyin*, Duan Guangcai. Rapid detection of HPV16/18 based on a CRISPR-Cas13a/Cas12a dual-channel system. Anal Methods 2022, 14(48): 5065-5075.

[16] Geng Juan, Liu Huiying, Chen Shuaiyin*, Long Jinzhao, Jin Yuefei, Yang Haiyan, Duan Guangcai. Comparative genomic analysis of Escherichia coli strains obtained from continuous imipenem stress evolution. FEMS Microbiol Lett 2022, 369(1).

[17] Hu Quanman, Cheng Cheng, Li Yang, Duan Guangcai, Chen Shuaiyin*. Elevated Creatine Kinase-MB Is an Independent Risk Factor for Mortality of COVID-19: Based on Adjusted Data. Arch Iran Med 2022, 25(2): 124-125.

[18] Long Jinzhao, Geng Juan, Xu Yake, Jin Yuefei, Yang Haiyan, Xi Yuanlin, Chen Shuaiyin*, Duan Guangcai. Large-Scale Phylogenetic Analysis Reveals a New Genetic Clade among Escherichia coli O26 Strains. Microbiol Spectr 2022, 10(1).

[19] Yuan Mingzhu, Ding Ronghua, Chen Shuaiyin*, Duan Guangcai. Advances in Field Detection Based on CRISPR/Cas System. ACS Synth Biol 2021, 10(11): 2824-2832.

[20] Ding Dong, Zhu Jingyuan, Gao Yanling, Yang Fan, Ma Yan, Cheng Xuemin, Li Jinlei, Dong Peng, Yang Haiyan, Chen Shuaiyin*. Effect of cattle farm exposure on oropharyngeal and gut microbial communities and antibiotic resistance genes in workers. Sci Total Environ. 2021 Sep 30:150685.

[21] Yang Fan, Gao Yanling, Zhao Hongcheng, Li Jinlei, Cheng Xuemin, Meng Lei, Dong Peng, Yang Haiyan, Chen Shuaiyin*, Zhu Jingyuan*. Revealing the distribution characteristics of antibiotic resistance genes and bacterial communities in animal-aerosol-human in a chicken farm: From One-Health perspective. Ecotoxicol Environ Saf. 2021 Aug 23;224:112687.

[22] Cheng Cheng, Zhang Dongdong, Dang Dejian, Geng Juan, Zhu Peiyu, Yuan Mingzhu, Liang Ruonan, Yang Haiyan, Jin Yuefie, Xie Jing, Chen Shuaiyin*, Duan Guangcai*. The incubation period of COVID-19: a global meta-analysis of 53 studies and a Chinese observation study of 11 545 patients. Infect Dis Poverty. 2021 Sep 17;10(1):119.

[23] Jin Yuefei, Li Dong, Sun Tiantian, Du Yue, Gao Yanlei, Ding Ronghua, Ji Wangquan, Zhang Weiguo, Yang Haiyan, Chen Shuaiyin*, Duan Guangcai*. Pathological Features of Enterovirus 71-Associated Brain and Lung Damage in Mice Based on Quantitative Proteomic Analysis. Front Microbiol. 2021 Jun 18;12:663019.

[24] Cheng Cheng, Zhang Dong, Chen Shuaiyin*, Duan Guangcai*. The association of cardiorespiratory fitness and the risk of hypertension: a systematic review and dose-response meta-analysis. J Hum Hypertens. 2021 Jun 24.

[25] Shen Yue, Cheng Cheng, Zheng Xue, Jin Yuefei, Duan Guangcai, Chen Mengshi, Chen Shuaiyin*. Elevated Procalcitonin Is Positively Associated with the Severity of COVID-19: A Meta-Analysis Based on 10 Cohort Studies. Medicina (Kaunas). 2021 Jun 9;57(6):594.

[26] Ding Ronghua, Long Jinzhao, Yuan Mingzhu, Jin Yuefie, Yang Haiyan, Chen Mengshi, Chen Shuaiyin*, Duan Guangcai*. CRISPR/Cas System: A Potential Technology for the Prevention and Control of COVID-19 and Emerging Infectious Diseases. Frontiers in Cellular and Infection Microbiology 2021;11:342.

[27] Ding Ronghua, Long Jinzhao, Yuan Mingzhu, Zheng Xue, Shen Yue, Jin Yuefei, Yang Haiyan, Li Hao, Chen Shuaiyin*, Duan Guangcai*. CRISPR/Cas12-Based Ultra-Sensitive and Specific Point-of-Care Detection of HBV. Int. J. Mol. Sci. 2021, 22, 4842.

[28] Yang Fan, Zhang Fengli, Li Hongping, Wu Huiying, Zhao Hongcheng, Cheng Xuemin, Ba Yue, Huang Hui, Chen Shuaiyin*, Zhu Jingyuan*. Contribution of environmental factors on the distribution of antibiotic resistance genes in agricultural soil. European Journal of Soil Biology 2021;102.

[29] Ou Liuyang, Long Jinzhao, Teng Yanli, Yang Haiyan, Xi Yuanlin, Duan Guangcai*, Chen Shuaiyin*. Diversity of the type I-U CRISPR-Cas system in Bifidobacterium. Arch Microbiol 2021.

[30] Li Dong^#, Chen Shuaiyin^#, Zhang Weiguo, Zhang Chao, Sun Tiantian, Du Yue, Ding Ronghua, Gao Yanlei, Jin Yuefei, Duan Guangcai. MicroRNA-628-5p Facilitates Enterovirus 71 Infection by Suppressing TRAF3 Signaling. CELL MOL IMMUNOL 2020.

[31] Chen Shuaiyin^#, Zheng Xin^#, Zhu Jingyuan^#, Ding Ronghua, Jin Yuefei, Zhang Weiguo, Yang HaiYan, Zheng Yingjuan, Li Xin, Duan Guangcai. Extended ORF8 Gene Region Is Valuable in the Epidemiological Investigation of Severe Acute Respiratory Syndrome-Similar Coronavirus. The Journal of Infectious Diseases 2020, 222(2): 223-233.

[32] Long Jinzhao, Xu Yake, Ou Liuyang, Yang Haiyan, Xi Yuanlin, Chen Shuaiyin*, Duan Guangcai*. Utilization of Clustered Regularly Interspaced Short Palindromic Repeats to Genotype Escherichia coli Serogroup O80. FRONT MICROBIOL 2020, 11.

[33] Gao Yanlei, Du Yue, Zhang Chao, Cheng Cheng, Yang Haiyan, Jin Yuefei, Duan Guangcai*, Chen Shuaiyin *. Role of Renin-Angiotensin System in Acute Lung Injury Caused by Viral Infection. Infection and Drug Resistance 2020;13:3715-3725.

[34] Zhao Hongcheng, Liu Jia, Zhu Jingyuan, Yang Fan, Wu Huiying, Ba Yue, Cui Liuxin, Chen Ruiying*, Chen Shuaiyin *. Bacterial composition and community structure of the oropharynx of adults with asthma are associated with environmental factors. Microb Pathog 2020;149:104505.

[35] Chen Shuaiyin, Liu Huiying, Liang Wenjuan, Hong Lijuan, Zhang Bing, Huang Lu, Guo Xiangjiao, Duan Guangcai. Insertion sequences in the CRISPR-Cas system regulate horizontal antimicrobial resistance gene transfer in Shigella strains. INT J ANTIMICROB AG 2019, 53(2): 109-115.

[36] Liu Qiaoli, Li Mengchen, Teng Yanli, Yang Haiyan, Xi Yuanli, Chen Shuaiyin*, Duan Guangcai*. The role of cfa gene in ampicillin tolerance in Shigella. INFECT DRUG RESIST 2019, 12: 2765-2774.

[37] Li Mengchen, Liu Qiaoli, Teng Yanli, Ou Liuyang, Xi Yuanlin, Chen Shuaiyin*, Duan Guangcai*. The resistance mechanism of Escherichia coli induced by ampicillin in laboratory. INFECT DRUG RESIST 2019, 12: 2853-2863.

[38] Long Jinzhao, Xu Yake, Ou Liuyang, Yang Haiyan, Xi Yuanlin, Chen Shuaiyin*, Duan Guangcai*. Polymorphism of Type I-F CRISPR/Cas system in Escherichia coli of phylogenetic group B2 and its application in genotyping. INFECT GENET EVOL 2019, 74(UNSP 103916).

[39] Chen Shuaiyin, Rongguang Zhang, Guangcai Duan. Pathogenic mechanisms of the oncoprotein CagA in H. pylori-induced gastric cancer (Review). ONCOL REP 2016, 36(6): 3087-3094.

[40] Chen Shuaiyin, Guangcai Duan, Rongguang Zhang, Qingtang Fan. Helicobacter pylori cytotoxin-associated gene A protein upregulates alpha-enolase expression via Src/MEK/ERK pathway: implication for progression of gastric cancer. INT J ONCOL 2014, 45(2): 764-770.

[41] Chen Shuaiyin, Rongguang Zhang, Guangcai Duan, Jianxiang Shi. Food-grade expression of Helicobacter pylori ureB subunit in Lactococcus lactis and its immunoreactivity. CURR MICROBIOL 2011, 62(6): 1726-1731.

l 著作

[1] 陈帅印（参编），《流行病实习教程第2版》，人民卫生出版社，2017。

[2] 陈帅印（参编），《流行病学实习教程解析》，郑州大学出版社，2017。

[3] 陈帅印（参编），《卫生统计学（案例版）》，科学出版社，2017。

[4] 陈帅印（参编），《实验室生物安全》，郑州大学出版社，2021。

l 专利

[1] 陈帅印，沈悦，段广才，袁明珠，龙金照，晋乐飞，杨海燕，一种可视化核酸检测装置，2022.09.27，中国，ZL202222582387.9

[2] 杨海燕，王瑛，杜悦，段广才，陈帅印，晋乐飞，基于CRISPR的试剂盒及其应用，2020.12.19，ZL202011512116.5

[3] 段广才，龙金照，徐亚珂，梁文娟，刘慧莹，陈帅印，杨海燕，郗园林.一种基于CRISPR的ST131系菌株检测引物、试剂盒及检测方法，2020.11.06，中国，ZL201611221446.2.

[4] 段广才，梁文娟，陈帅印，张荣光，杨海燕，张卫东，范清堂，郗园林.基于特异序列的大肠杆菌和志贺菌检测引物、试剂盒及检测方法，2020.08.28，中国，ZL201611220011.6.

[5] 段广才, 张荣光, 乔丹, 范清堂, 张卫东, 郗园林, 陈帅印. 一种乳酸乳球菌表达载体及其制备方法与应用，2015.2.4，中国，ZL201210218281.9.