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正高

杨永利

教授,硕士研究生导师、计算机与卫生统计学教研室主任

研究方向:卫生服务统计方法与应用;临床试验设计与评价


邮箱:ylyang377@zzu.edu.cn


一、基本介绍

杨永利,女,教授,硕士研究生导师,计算机与卫生统计学教研室主任。1998年6月获学士学位(河南医科大学预防医学专业),2002年获医学硕士学位(郑州大学流行病与卫生统计学专业),2010年获医学博士学位(郑州大学流行病与卫生统计学专业),2016年至2017年期间在美国Yale University医学院做访问学者。近年来,主持/参与国家级项目6;全球基金艾滋病项目5项;省级和厅级课题15项;承担横向科研项目100余项。编写著作13部;发表中文核心SCI论文150余篇;出版词典1部;获河南省科技进步二等奖2项、国家发明专利6项、计算机软件著作权登记1项、校级和厅级成果15项等奖项

二、教育/工作经历

l 工作经历

[1]. 2020.08-至今郑州大学公共卫生学院教授

[2]. 2011.04-2020.08郑州大学公共卫生学院副教授

[3]. 2006.05-2011.04郑州大学公共卫生学院讲师

[4]. 2002.07-2006.05郑州大学公共卫生学院助教

l 教育经历

[1]. 2016.10-2017.10美国耶鲁大学访问学者

[2]. 2005.09-2009.12郑州大学流行病与卫生统计学博士

[3]. 1999.09-2002.07郑州大学流行病与卫生统计学硕士

[4]. 1993.09-1998.06郑州大学(原河南医科大学)预防医学,学士

三、学术荣誉/学术兼职

l 学术荣誉

[1]. 2021年中共河南省党委组织部:河南省新冠肺炎疫情防控嘉奖

[2]. 2021年河南省优秀硕士学位论文指导教师

[3]. 2021年郑州大学科技服务社会先进个人


l 学术兼职

[1]. 河南省医学传播学会 副会长

[2]. 河南省预防医学会艾滋病防治专业委员会 副主任委员

[3]. 河南省中西医结合循证医学专业委员会 副主任委员

[4]. 中国初级卫生保健基金会医学统计公益基金专业委员会 常委委员

[5]. 郑州大学学报(医学版)审稿专家


四、主持科研项目

[1]. 教育部人文社会科学研究规划基金中国育龄妇女生育水平的时空演变及其驱动因素(项目编号:23YJAZH178.起止时间:2023-2025. 主持.

[2]. 河南省高等学校重点科研项目:基于机器学习模型挖掘宫颈癌肿瘤免疫微环境特征生物标志物项目编号:23B330001.起止时间:2023-2024. 主持.

[3]. 郑州大学百个教授团队助力企业高质量创新发展驱动专项.起止时间:2021-2022. 主持.

[4]. 2020年国家自然科学基金:基于多元统计建模的代谢综合征遗传易感性和生物机制研究项目编号:82073670.起止时间:2021-2024. 2.

[5]. 国家“十三五”科技重大专项子课题:普通人群HIV新发感染监测队列研究(项目编号:2018ZX10715009.起止时间:2018-2020. 参与.

[6]. 国家“十二五”科技重大专项分课题:示范区重大传染病规模化现场流行病学调查和干预质量控制研究(项目编号:2014ZX10004008).起止时间:2014-2017. 主持.

[7]. 横向项目:随机、盲法、同类疫苗对照设计评价冻干人用狂犬病疫苗(人二倍体细胞)以不同免疫程序接种于10-60岁人群的免疫原性和安全性的I期+III期临床试验(项目编号:20230381A.起止时间:2023-2028. 主持.

[8]. 横向项目:重组带状疱疹疫苗(CHO 细胞)I期临床试验(项目编号:20230075A.起止时间:2023-2025. 主持.

[9]. 横向项目:新型冠状病毒灭活疫苗国际多中心Ⅲ期临床试验(项目编号20200555A.起止时间:2020-2024. 主持.

[10]. 横向项目:新型冠状病毒灭活疫苗(vero细胞)Ⅰ/Ⅱ期临床试验(项目编号:20200232A.起止时间:2020-2024. 主持.

[11]. 横向项目b型流感嗜血杆菌结合疫苗Ⅰ期、Ⅲ期临床试验(项目编号:20190452A.起止时间:2019-2024. 主持.

[12]. 横向项目AC-Hib和肺炎疫苗临床试验评价(项目编号:20190326A..起止时间:2019-2024. 主持.

五、代表性成果

l 论文

[1] Bin Wang, Yongyue Chen, Wenxuan Li, Yuwei Liu, Xinli Xu, Lei Ma, Xia Xu,Xuezhong Shi, Yongli Yang*, Di Chen*. Conveniently monitoring aldehyde changes in heated edible oils using miniaturized kapok fiber-supported liquid-phase extraction/in-situ derivatization coupled with liquid chromatography-tandem mass spectrometry. Food Chemistry. 2023. (中科院1区,IF=8.8)

[2] Mingyi Xue, Xiaocan Jia, Xuezhong Shi, Chaojun Yang, Rensong Wang, Chenyu Zhao, Xin Xin, Yongli Yang*. Association between Sarcopenia and Cognitive Trajectories among Middle- Aged and Older Adults in China: A Nationally Representative Cohort Study. J Nutr Health Aging. 2023. (中科院3区,IF=5.285)

[3] Yongli Yang, Xin Xin, Peinan Chen, Xuezhong Shi, Chaojun Yang, Jingwen Fan, Yi Zhan, Xiaocan Jia*. Left compared with right thoracic approach thoracotomy in esophageal cancer: a retrospective cohort study. Journal of Cancer Research and Clinical Oncology. 2023. (中科院3区,IF=4.322)

[4] Nana Wang, Abiyasi Nanding, Xiaocan Jia, Yuping Wang, Chaojun Yang, Jingwen Fan, Ani Dong, Guowei Zheng,Jiaxin Ma, Xuezhong Shi* and Yongli Yang*.Mining of immunological and prognostic-related biomarker for cervical cancer based on immune cell signatures. Front. Immunol. 2022. (中科院2区, IF=8.786)

[5] Xuezhong Shi, Ani Dong, Xiaocan Jia, Guowei Zheng, Nana Wang, Yuping Wang, Chaojun Yang, Jie Lu and Yongli Yang*. Integrated analysis of single-cell and bulk RNA-sequencing identifies a signature based on T-cell marker genes to predict prognosis and therapeutic response in lung squamous cell carcinoma. Front. Immunol. 2022. (中科院2区,IF=8.786)

[6] Chenyu Zhao, Xiaocan Jia, Yuping Wang, Zixiao Luo, Jingwen Fan, Xuezhong Shi, Yongli Yang*. Overlapping genetic susceptibility of seven autoimmune diseases: SPU tests based on genome-wide association summary statistics. Gene. 2023. (中科院2区, IF=4.070)

[7] Jiao Lian, Xuezhong Shi, Xiaocan Jia, Jingwen Fan, Yuping Wang, Yang Zhao, and Yongli Yang*. Genetically predicted blood pressure, antihypertensive drugs and risk of heart failure: a Mendelian randomization study. Journal of Hypertension. 2022. (中科院2区,IF=4.844)

[8] Zhenqing Yang, Fan Pu, Xingqi Cao, Xueqin Li, Sudan Sun, Jingyun Zhang, Chen Chen, Liyuan Han, Yongli Yang, Wei Wang, Yawei Zhang, Zuyun Liu*. Does healthy lifestyle attenuate the detrimental effects of urinary polycyclic aromatic hydrocarbons on phenotypic aging? An analysis from NHANES 2001–2010. Ecotoxicology and Environmental Safety. 2022.(中科院1区, IF=7.129

[9] Yongli Yang, Jingwen Fan, Xuezhong Shi, Yuping Wang, Chaojun Yang, Jiao Lian, Nana Wang, Chenyu Zhao, Yang Zhao and Xiaocan Jia *. Causal associations between sleep traits and four cardiac diseases: a Mendelian Randomization study. ESC Heart Failure. 2022.(中科院2区, IF=4.111)

[10] Yuping Wang, Jiebing Tan, Wei Wang, Xiaoran Duan, Brooke Lappe, Liuhua Shi, Yongli Yang*, Xuezhong Shi*. The association between polymorphisms in cell-cycle genes and mitochondrial DNA copy number in coke oven workers. Frontiers in Public Health. 2022. (中科院3区,IF=6.461)

[11] Yongli Yang, Nana Wang, Xuezhong Shi, Yuping Wang, Chaojun Yang, Jingwen Fan, Xiaocan Jia*. Construction of an immune infiltration landscape based on immune-related genes in cervical cancer. 2022. (中科院1区,IF=6.698)

[12] Huili Zhu, Xiaocan Jia, Yuping Wang, Zhijuan Song, Nana Wang, Yongli Yang* and XuezhongShi*. M6A Classification Combined With Tumor Microenvironment Immune Characteristics Analysis of Bladder Cancer. Frontiers in Oncology. 2021. (中科院2区,IF=6.244).

[13] Jingwen Fan, Xuezhong Shi, Xiaocan Jia, Yuping Wang, Yang Zhao, Junzhe Bao, Haomin Zhang, and Yongli Yang*. Birthweight, childhood obesity and risk of hypertension: a Mendelian randomization study. Journal of Hypertension. 2021. (中科院2区,IF=4.844).

[14] Xuening Zhang, Xuezhong Shi, Hao Zhao, Xiaocan Jia, Yongli Yang*. Identification and Validation of A Tumor Microenvironment-related Gene Signature for Prognostic Prediction in Advanced-stage Non-small Cell Lung Cancer. Biomed Research International. 2021. (中科院 3区,IF=3.411)

[15] Xuening Zhang, Hao Zhao, Xuezhong Shi, Jie Lu, Xiaocan Jia, Yongli Yang*. Identification and validation of an immune-related gene signature predictive of overall survival in colon cancer. Aging US. 2020. (中科院1区IF=5.682)

[16] Shengli Xia, Yuntao Zhang, Yanxia Wang, Hui Wang, Yunkai Yang, George Fu Gao, Wenjie Tan, Guizhen Wu, Miao Xu, Zhiyong Lou, Weijin Huang, Wenbo Xu, Baoying Huang, Huijuan Wang, Wei Wang, Wei Zhang, Na Li, Zhiqiang Xie, Ling Ding, Wangyang You, Yuxiu Zhao, Xuqin Yang, Yang Liu, Qian Wang, Lili Huang, Yongli Yang, Guangxue Xu, Bojian Luo, Wenling Wang, Peipei Liu, Wanshen Guo, Xiaoming Yang. Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBIBP-CorV: a randomised, double-blind, placebo-controlled, phase 1/2 trial. Lancet Infect Dis. 2020. (中科院1区IF=24.446高被引)

[17] Shengli Xia, Kai Duan, Yuntao Zhang, Dongyang Zhao, Huajun Zhang, Zhiqiang Xie, Xinguo Li, Cheng Peng, Yanbo Zhang, Wei Zhang, Yunkai Yang, Wei Chen, Xiaoxiao Gao, Wangyang You, XueweiWang, ZejunWang, Zhengli Shi, YanxiaWang, Xuqin Yang, Lianghao Zhang, Lili Huang, QianWang, Jia Lu, Yongli Yang, Jing Guo, Wei Zhou, XinWan, CongWu, WenhuiWang, Shihe Huang, Jianhui Du, Ziyan Meng, An Pan, Zhiming Yuan, Shuo Shen, Wanshen Guo, Xiaoming Yang. Effect of an Inactivated Vaccine Against SARS-CoV-2 on Safety and Immunogenicity Outcomes Interim Analysis of 2 Randomized Clinical Trials. JAMA. 2020. (中科院1区, IF=45.54高被引)

[18] Xiaoran Duan, Daping Zhang, Sihua Wang, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Mingcui Ding, Hui Zhang, Bin Liu, Wan Wei, Reuben Mensah Acquaye, Wu Yao, Liuxin Cui, Xiaoshan Zhou, Wei Wang, Yongli Yang*. Effects of polycyclic aromatic hydrocarbon exposure and miRNA variations on peripheral blood leukocyte DNA telomere length: A cross-sectional study in Henan Province, China. Science of the Total Environment. 2020. (中科院2区, IF=5.589)

[19] Xiaocan Jia, Nian Shi, Yu Feng, Yifan Li, Jiebing Tan, Fei Xu, Wei Wang, Changqing Sun, Hongwen Deng, Yongli Yang* and Xuezhong Shi*. Identification of 67 Pleiotropic Genes Associated With Seven Autoimmune/Autoinflammatory Diseases Using Multivariate Statistical Analysis. Frontiers in Immunology. 2020. (中科院2区, IF=4.716)

[20] Yongli Yang, Jiebing Tan, Xiaoran Duan, Hui Zhang, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Mingcui Ding, Suxiang Liu, Lei Li, Haiyong Liang, Wu Yao, Wei Wang, Xiaoshan Zhou*. The association between polymorphisms in tankyrase gene and telomere length in omethoate-exposed workers. Chemosphere. 2020. (中科院2区, IF=5.108)

[21] Yang YongliZhiwei Cheng, Xiaocan Jia, Nian Shi, Zhenhua Xia, Weiping Zhang, Xuezhong Shi*. Mortality trends of bladder cancer in China from 1991 to 2015: an age-period-cohort analysis. Cancer Management and Research. 2019. (中科院2区, IF=3.702)


l 著作

[1] 杨永利 主编. SPSS医学数据分析教程(卫生统计学实习指导). 郑州郑州大学出版社. 2023.

[2] 杨永利 编委. Statistical Methods for Biomedical Research. World Scientific. 2021.

[3] 杨永利 编委. 生物医学研究的统计方法(第2版). 北京:高等教育出版社. 2019.

[4] 杨永利 编委. 临床医学导论. 北京:人民卫生出版社. 2018年.

[5] 杨永利 编委. 高级医学统计学. 北京:科学出版社. 2014年.


l 成果/专利

[1] 计算机软件著作权登记:中央随机系统V1.0. 2021年. 1.

[2] 河南省科技进步二等奖:氯乙烯作业工人染色体损伤生物标志物评价与应用.河南省人民政府(2018-J-113-RO4/10). 2019年. 4.

[3] 河南省科技进步二等奖:艾滋病综合防治居民健康档案信息管理平台设计与应用(2014-J-133-R03/10). 2014年. 第3.

[4] 国家发明专利:人对氧磷酶2基因148位点G/A多态检测试剂盒(专利号:ZL2011104406468). 2013年. 第1.

[5] 国家发明专利:用BsrFI鉴定人MTHFR基因多态性rs2274976的试剂盒(专利号:ZL201210091430X). 2013年. 1.