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正高

姚武

教授、博士生导师、学科方向带头人

研究方向:职业性呼吸系统疾病,致力于尘肺病及职业性肿瘤免疫发病机制、早期预警、预防及控制研究


联系电话:0371-67781918

邮箱:yaowu@zzu.edu.cn


一、基本介绍


姚武,男,1962年生,公共卫生学院学科方向带头人、教授1984年毕业于北京医学院获医学学士学位,2005年毕业于四川大学获医学博士学位,2012年—2013年赴美国德克萨斯州立大学做访问学者。目前从事职业卫生与职业医学的教学、科研工作,主要研究方向为职业性呼吸系统疾病,致力于尘肺病及职业性肺癌免疫发病机制、早期预警、预防和控制研究。先后获得多项国家自然科学基金及省、厅级资助课题,获河南省科技进步二等奖3项、国家发明专利8项,发表学术论文110余篇(第一作者及通讯作者50余篇)作为主编或参编著作/教材10余部。曾获河南省教育厅学术及技术带头人、河南省优秀教师、河南省学位点建设与研究生教育工作先进个人、“三育人”先进个人等荣誉称号。学术兼职:中国毒理学会免疫毒理专业委员会副主任委员兼秘书长,河南省医学会公共卫生专业委员会副主任委员,河南省预防医学会劳动卫生职业病专业委员会副主任委员。


二、教育/工作经历

工作经历:

[1] 2021-至今,2006-12至现在,郑州大学,公共卫生学院,教授

[2] 2000-6至2006-11,郑州大学,公共卫生学院,副教授

[3] 1996-11至2000-5,河南医科大学,公共卫生学院,副教授

[4] 1991-11至1996-10,河南医科大学,公共卫生学院,讲师

[5] 1984-7至1991-10,河南医科大学,公共卫生学院,助教

教育经历:

[1] 2012至2013年赴美国德克萨斯州立大学做访问学者

[2] 2002-09至2005-07,四川大学,公共卫生学院,博士,导师:王治明教授

[3] 1979-09至1984-07,北京医学院,学士



三、学术荣誉/学术兼职

l 学术荣誉

[1] 2017年 河南省文明教师 中共河南省委高校工委、河南省教育厅

[2] 2014年 河南省科学技术进步二等奖1项 河南省人民政府

[3] 2007年 河南省学位点建设与研究生教育工作先进个人 河南省学位委员会和河南省教育厅

[4] 2007年 河南省优秀教师 河南省教育厅

[5] 2007年 郑州大学优秀党务工作者 中共郑州大学委员会

[6] 2000年 河南省卫生厅医药卫生科技成果二等奖1项 河南省卫生厅

[7] 2005年 河南省科学技术进步二等奖1项 河南省人民政府

[8] 1999年 河南省科学技术进步二等奖1项 河南省人民政府


l 国内学会与学术期刊

[1] 2018年11月中国毒理学会常务理事兼免疫毒理专业委员会主任委员

[2] 2017年11月中国环境诱变剂学会常务理事兼致癌专业委员会副主任委员

[3] 2016年11月河南省预防医学会常务理事兼职业卫生与职业医学分会副主任委员



四、主持科研项目

[1] 国家自然科学基金委员会,国家自然科学基金联合专项项目,82241093,基于纳米石墨烯吸入体内的代谢转归筛选暴露生物标志物,2023-012025-1252万,在研,主持

[2] 国家自然科学基金委员会,国家自然科学基金联合基金项目,U1904209,瓦斯爆炸肺损伤分子机制及间充质干细胞及其外泌体修复作用研究,2020-01至2023-12,218万,已结题,参加

[3] 国家自然科学基金委员会,国家自然科学基金面上项目,81773404,外泌体miRNA介导的细胞间通讯在实验性矽肺发生发展中的作用,2018-01至2021-12,60万,已结题,主持

[4] 国家自然科学基金委员会,国家自然科学基金面上项目,81472954,循环纤维细胞的类干细胞特性及其在矽肺中的作用、机制与生物标志价值,2015-01至2018-01,85万,已结题,主持

[5] 国家自然科学基金委员会,国家自然科学基金面上项目,81273039,树突状细胞在实验性矽肺发生发展中的作用与机制,2013-01至2016-12,60万,已结题,主持

[6] 国家自然科学基金委员会,国家自然科学基金青年基金项目, 81102109,二氧化硅粉尘诱导肺成纤维细胞转分化的表观遗传学调控机制, 2012-1至2014-12,21万,已结题,参加

[7] 国家自然科学基金委员会,国家自然科学基金面上项目, 81072278,人源尘肺病噬菌体单链抗体库的构建及筛选,2011-1至2013-12,33万,已结题,主持


五、代表性成果


l 论文

[1] Zhao Y, Qu Y, Duan M, Hao C, Yao W. Dynamics of the inhibitory immune checkpoint TIM-3 in mouse pulmonary phagocytes after silica exposure. Ecotoxicol Environ Saf. 2023;261:115087.

[2] Qu Y, Zhai R, Wang D, Wang Z, Hou G, Wu C, Tang M, Xiao X, Jiao J, Ba Y, Zhou F, Qiu J, Yao W. Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis. J Transl Med. 2023 Jun 6;21(1):365.

[3] Deng M, He J, Hao C, Guo Y, Si H, Deng X, Zhang C, Li S, Yao S, Ren W, Yao W. Effect of exosomes derived from bone marrow mesenchymal stem cells on programmed cell death in blast-induced lung injury in rats. Shock. 2023;59(6):955-965.

[4] Zhao Y, Qu Y, Hao C, Yao W. PD-1/PD-L1 axis in organ fibrosis. Front Immunol. 2023;14:1145682.

[5] Deng X, Niu Z, Hao C, Lin J, Yao W. HMGB1 coordinates with Brahma-related gene 1 to promote epithelial-mesenchymal transition via the PI3K/Akt/mTOR pathway in BEAS-2B cells. Exp Cell Res. 2023;424(2):113522.

[6] Tian Y, Xia J, Yang G, Li C, Qi Y, Dai K, Wu C, Guo Y, Yao W, Hao C. A2aR inhibits fibrosis and the EMT process in silicosis by regulating Wnt/β-catenin pathway. Ecotoxicol Environ Saf. 2023;249:114410.

[7] Dai K, Wang C, Yao W, Hao C. Expression level and function analysis of serum miRNAs in workers with occupational exposure to benzene series. Chemosphere. 2023;313:137460.

[8] Guo Y, Deng X, Dai K, Deng M, He J, Si H, Xu X, Niu Z, Wang C, Yao W, Hao C. Benchmark dose estimation based on oxidative damage in Chinese workers exposed to benzene series compounds. Environ Toxicol Pharmacol. 2023;100:104150.

[9] Xia J, Tian Y, Shao Z, Li C, Ding M, Qi Y, Xu X, Dai K, Wu C, Yao W, Hao C. MALAT1-miR-30c-5p-CTGF/ATG5 axis regulates silica-induced experimental silicosis by mediating EMT in alveolar epithelial cells. Ecotoxicol Environ Saf. 2023;249:114392.

[10] Ding M, Pei Y, Zhang C, Qi Y, Xia J, Hao C, Yao W. Exosomal miR-125a-5p regulates T lymphocyte subsets to promote silica-induced pulmonary fibrosis by targeting TRAF6. Ecotoxicol Environ Saf. 2023;249:114401.

[11] Li X, Zhao C, Li C, Zhang M, Xie Y, Feng F, Yao W, Wang N. Detection and analysis of lung microbiota in mice with lung cancer lacking the NLRP3 gene. Biochem Biophys Res Commun. 2023;639:117-125.

[12] Zhou R, Jin C, Jiao L, Zhang S, Tian M, Liu J, Yang S, Yao W, Zhou F. GGA (geranylgeranylacetone) ameliorates bleomycin-induced lung inflammation and pulmonary fibrosis by inhibiting apoptosis and oxidative stress. Mol Biol Rep. 2023;50(9):7215-7224.

[13] Zhou R, Jin C, Jiao L, Zhang S, Tian M, Liu J, Yang S, Yao W, Zhou F. Geranylgeranylacetone, an inducer of heat shock protein 70, attenuates pulmonary fibrosis via inhibiting NF-κB/NOX4/ROS signalling pathway in vitro and in vivo. Chem Biol Interact. 2023;382:110603.

[14] Zhao Y, Hao C, Li M, Qu Y, Guo Y, Deng X, Si H, Yao W. PD-1/PD-L1 inhibitor ameliorates silica-induced pulmonary fibrosis by maintaining systemic immune homeostasis. Biomed Pharmacother. 2022 Apr;148:112768.

[15] Y Qu, Bao L., Zhao Y., Li Y., Ding M., Hao C., Yao W. Dendritic cells activated by cimetidine induce Th1/Th17 polarization in vitro and in vivo [J]. Toxicol In Vitro, 2022, 83(105395.

[16] Liu S, Yao W. Prediction of lung cancer using gene expression and deep learning with KL divergence gene selection. BMC Bioinformatics. 2022;23(1):175.

[17] Li Y, Cheng Z, Fan H, Hao C, Yao W. Epigenetic Changes and Functions in Pneumoconiosis. Oxid Med Cell Longev. 2022;2022:2523066.

[18] Deng X, Hao C, Li Y, Guo Y, Si H, He J, Deng M, Niu Z, Wang C, Xu X, Dai K, Yao W. Lysophosphatidylcholine acyltransferase 1 alleviates silica-induced pulmonary fibrosis by modulating lipid metabolism. Biomed Pharmacother. 2022;155:113638.

[19] Bao L, Hao C, Wang J, Guo F, Geng Z, Wang D, Zhao Y, Li Y, Yao W. In vitro co-culture model of human monocyte-derived dendritic cells and T cells to evaluate the sensitization of dinitrochlorobenzene. Ecotoxicol Environ Saf. 2021 Sep 1;220:112331.

[20] Zhao Q, Hao C, Wei J, Huang R, Li C, Yao W. Bone marrow-derived mesenchymal stem cells attenuate silica-induced pulmonary fibrosis by inhibiting apoptosis and pyroptosis but not autophagy in rats. Ecotoxicol Environ Saf. 2021 Apr 10;216:112181.

[21] Huang R, Hao C, Wang D, Zhao Q, Li C, Wang C, Yao W. SPP1 derived from silica-exposed macrophage exosomes triggers fibroblast transdifferentiation. Toxicol Appl Pharmacol. 2021 Jul 1;422:115559.

[22] Wei J, Zhao Q, Yang G, Huang R, Li C, Qi Y, Hao C, Yao W. Mesenchymal stem cells ameliorate silica-induced pulmonary fibrosis by inhibition of inflammation and epithelial-mesenchymal transition. J Cell Mol Med. 2021 Jun 2;25(13):6417–28.

[23] Wu Yao; Peiyan Yang; Yuanmeng Qi; Luheng Jin; Ahui Zhao; Mingcui Ding; Di Wang; YiPing Li;Changfu Hao*; Transcriptome analysis reveals a protective role of liver X receptor alpha against silica particle-induced experimental silicosis,Science of the Total Environment, 2020, 747: 141531.

[24] Qu YQ, Hao CF, Zhai RN, Yao W. Folate and macrophage folate receptor-beta in idiopathic pulmonary fibrosis disease: the potential therapeutic target?. Biomed Pharmacother. 2020; 131: 110711.

[25] Wang D, Hao CF, Zhang L, Zhang JH, Liu SN, Li YP, Qu YQ, Zhao YL, Huang RX, Wei JJ, Yao W. Exosomal miR-125a-5p derived from silica-exposed macrophages induces fibroblast transdifferentiation. Ecotoxicol Environ Saf. 2020; 192: 110253.

[26] Zhao YL, Hao CF, Bao L, Wang D, Li YP, Qu YQ, Ding MC, Zhao AH, Yao W. Silica particles disorganize the polarization of pulmonary macrophages in mice. Ecotoxicol Environ Saf. 2020; 193: 11.364.

[27] Yao W, Ding MC, Bao L, Zhao YL, Wang D, Li YP, Qu YQ, Hao CF. Human monocyte-derived dendritic cells as an in vitro alternative model cell to evaluate the immunotoxicity of 2, 4-Dinitrochlorobenzene. Toxicology letters. 2020, 330: 118-127.

[28] Wu JJ, Wang HX*, Yao W*, Yan Z, Pei JJ. Late-life depression and the risk of dementia in 14 countries: a 10-year follow-up study from the Survey of Health, Ageing and Retirement in Europe. Journal of affective disorders. 2020; 274: 671-677.

[29] Bao L, Hao CF, Wang J, Wang D, Zhao YL, Li YP, Yao W. High-Dose Cyclophosphamide Administration Orchestrates Phenotypic and Functional Alterations of Immature Dendritic Cells and Regulates Th Cell Polarization. Frontiers in pharmacology. 2020; 11: 775.

[30] Liu SN, Hao CF, Bao L, Zhao DH, Zhang HY, Hou JY, Wang D, Chen HT, Feng FF, Yao W. Silica Particles Mediate Phenotypic and Functional Alteration of Dendritic Cells and Induce Th2 Cell Polarization. Frontiers in Immunology. 2019;10.

[31] Qiao YM, Lu YK, Yan Z, Yao W*, Pei JJ, Wang HX*. Reciprocal associations between job strain and depression: A 2-year follow-up study from the Survey of Health, Ageing and Retirement in Europe. Brain and behavior. 2019, 9(9): e01381.

[32] Zhao YL, Hao CF, Zhai RN, Bao L, Wang D, Li YP, Yu XH, Huang RX, Yao W. Effects of cyclophosphamide on the phenotypes and functions of THP-1 cells. Environ Toxicol Pharmacol. 2019; 70: 103201.

[33] Yu XH, Zhai RN, Hua BY, Bao L, Wang D, Li YP, Yao W*, Fan H*, Hao CF*. miR-let-7d attenuates EMT by targeting HMGA2 in silica-induced pulmonary fibrosis. Rsc advances. 2019; 9(34): 19355-19364.

[34] Bao L, Hao CF, Liu SN, Zhang L, Wang J, Wang D, Li YP, Yao W*. Dendritic cells trigger imbalance of Th1/Th2 cells in silica dust exposure rat model via MHC-II, CD80, CD86 and IL-12. Rsc Advances. 2018;8(46):26108-26115.

[35] Zhang L, Hao CF, Yao SQ, Tang R, Guo W, Cong HB, Li JF, Bao L, Wang D, Li YP, Yu XH, Duan SY, Yao W*. Exosomal miRNA Profiling to Identify Nanoparticle Phagocytic Mechanisms. Small. 2018;14(15).

[36] Zhang L, Hao CF, Zhai RN, Wang D, Zhang JH, Bao L, Li YP, Yao W*. Downregulation of exosomal let-7a-5p in dust exposed- workers contributes to lung cancer development. Respiratory Research. 2018;19.

[37] Zhang L, Li JF, Hao CF, Guo W, Wang D, Zhang JH, Zhao YL, Duan SY, Yao W*. Up-regulation of exosomal miR-125a in pneumoconiosis inhibits lung cancer development by suppressing expressions of EZH2 and hnRNPK. Rsc Advances. 2018;8(47):26538-26548.


l 著作

[1] 姚武(编委),预防医学(第版),人民卫生出版社,2022

[2] 姚武(编委),预防医学(第版),人民卫生出版社,2023

[3] 姚武(编委),职业卫生与职业医学(第八版),人民卫生出版社,2017

[4] 姚武(编委),职业卫生与职业医学(第七版),人民卫生出版社,2012

[5] 姚武(编委),卫生法律制度与监督学(第三版),人民卫生出版社,2013

[6] 姚武(编委),预防医学(7、8年制临床医学专业使用,第二版),人民卫生出版社,2015

[7] 姚武(副主编),卫生法学纲要,复旦大学出版社(第五版),2014