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毛振兴

教授、博士生导师河南省高层次人才、公共卫生学院副院长


研究方向:环境流行病学、重大代谢性疾病风险评估和医学统计方法的应用


联系电话:0371-67731737

邮箱:mzx@zzu.edu.cn


一、基本介绍

毛振兴,1988年出生,医学博士,教授,博士生导师,公共卫生学院副院长,26届河南青年五四奖章获得者,河南省高层次人才,河南省中原青年拔尖人才,河南省高校科技创新人才,河南省青年骨干教师河南省省级样板党支部书记。主持国家重点研发计划重点专项课题/子课题、国家自然科学基金面上项目等国家级课题4项、中国博后课题2项、省级及其他课题13项。近三年,以第一/通讯作者在International Journal of EpidemiologyEnvironment International等发表论文40余篇,其中高被引论文和热点论文2篇。获省部级科学技术进步奖贰等奖”1项,厅级科技成果壹等奖”3项;厅级优秀科技论文奖壹等奖”2项。参编教材及学术专著2部。Eco-Environment&Health杂志Handling Editor、《环境与职业医学》杂志青年编委、《医学动物防制》编委。中国毒理学会青年委员、中国健康管理协会标准化与评价分会理事中华预防医学会甲状腺疾病防治专业委员会委员、中国环境诱变剂学会致突变专业委员会青年委员、河南省临床流行病学与循证医学专业委员会委员。

1)环境与健康:从设计精细的人群多途径、多时点的前瞻性研究入手,分析环境和生物样本中的环境污染物(农药、PAHsPCBsPBDEs等)含量、分布特征和时间变化趋势,阐明其生物累积特性,明确人群暴露的主要途径,提出准确的人群暴露评估方法;通过队列随访明确环境污染物暴露对代谢性疾病发生的关联和剂量效应关系;分析环境污染物暴露对体内性激素水平的影响,明确其潜在的内分泌干扰效应,初步探明环境污染物暴露对代谢性疾病的作用及可能机制;结合体内、体外实验模拟人体真实暴露场景,明确环境污染物暴露对机体代谢性疾病及其相应靶器官结构和功能的影响,探明对代谢性疾病作用的相关通路基因和蛋白表达改变情况,阐明环境污染物暴露对代谢性疾病作用的分子机制。整合人群流行病学和动物实验数据,基于传统危险因素和环境危险因素,构建和优化慢性代谢性疾病发病风险评估模型,实验个体化诊疗和精准预防。

2)重大代谢性疾病风险评估:中医与预防医学及暴露组学、基因组学、代谢学等多组学相结合,通过人工智能、深度学习等数据挖掘技术,应用成熟可靠的中医健康状态辨析的方法与技术,将中医指标与暴露组学、基因组等多组学及传统危险因素相结合,建立心脑血管疾病等重大慢病的风险评估和预警模型。将四诊信息、症状体征、生化指标、气象信息等因素,通过聚类分析、人工神经网络、支持向量机、决策树等数据挖掘技术,构建心脑血管疾病中医风险评估和预警模型,建立个体化的疾病风险评估系统,为心脑血管疾病发病和复发加重风险的预测提供了新的思路和方法。

3)皮肤表面脂质组学基础与应用研究。基于脂质组学研究不同年龄、不同部位、不同皮肤类型皮肤表面的脂质成分,以及长期使用洗涤剂对皮肤表面脂质的影响。为探索皮肤问题发生机制及皮肤屏障功能保护提供参考依据。

二、教育/工作经历

工作经历:

[1] 2024-03至今, 郑州大学, 公共卫生学院, 教授/博士生导师

[2] 2020-052024-03, 郑州大学, 公共卫生学院, 副教授/博士生导师

[3] 2015-072020-05, 郑州大学, 公共卫生学院, 讲师

教育经历:

[1] 2010-092015-06, 华中科技大学, 同济医学院公共卫生学院,博士,导师:徐顺清

[2] 2005-092010-06, 中南大学, 湘雅医学院公共卫生学院, 本科

4. 主要学术荣誉和学术兼职

三、学术荣誉/学术兼职

4.1 学术荣誉:

2023年 河南省高层次人才

2022 中原青年拔尖人才

2022年 河南青年五四奖章获得者

2021年 河南省高校科技创新人才

2021年 河南省高等学校青年骨干教师

2021年 郑州大学优秀青年人才创新团队

2021年 郑州大学优秀青年人才企业创新团队

2020年 河南省科学技术进步奖贰等奖

2018年 郑州大学青年骨干教师

4.2 学术兼职:

2023 中国毒理学会 青年委员

2023中国健康管理协会标准化与评价分会 理事

2021年《Eco-Environment&Health》杂志 青年编委/Handling Editor

2021年《环境与职业医学》杂志 青年编委

2021年 河南省临床流行病学与循证医学专业委员会 委员

2020年 中国环境诱变剂学会致突变专业委员会 青年委员

2019年 中华预防医学会甲状腺疾病防治专业委员会 委员

四、主持科研项目

(1) 国家重点研发计划中医药现代化研究重点专项课题, 2019YFC1710002, 心脑血管疾病中医风险评估和预警模型研究, 2019-2021

(2) 国家重点研发计划常见多发病防治研究重点专项子课题,  2023YFC2506505, 泛血管动脉粥样硬化的无创评估、危险分层与精准治疗策略研究及推广, 2023-2026

(3) 国家自然科学基金, 面上项目, 42177415, 基于农村队列的新烟碱类农药环境暴露对2型糖尿病的作用研究, 2022-2025

(4) 国家自然科学基金青年项目, 21607136, 围产期双酚S暴露致胰岛β细胞损伤的IGF2/H19表观遗传学机制研究, 2017-2019

(5) 中国博士后科学基金, 特别资助项目, 2020T130604, 基于农村队列研究类固醇激素代谢及其相关DNA甲基化在2型糖尿病发病中的作用, 2021-2022

(6) 中国博士后科学基金, 面上项目, 2016M602264, 砷、镉内暴露与KCNQ1基因多态性对2型糖尿病的交互作用, 2016-2018

(7) 省科技研发计划联合基金, 232301420059, 基于农村人群前瞻性队列的新烟碱类农药环境暴露对肥胖影响及作用机制研究, 2024-2025

(8) 中原英才计划(育才系列)-中原青年拔尖人才(自然科学和工程技术类), 2023

(9) 河南省高校科技创新人才, 22HASTIT044, 环境与慢性代谢性疾病流行病学, 2022-2024

(10) 河南省高等学校青年骨干教师计划, 2021GGJS015, 性激素及其受体DNA甲基化在糖尿病发病中的作用, 2022-2023

(11) 河南省科技厅, 科技攻关, 202102310046, 类固醇激素代谢网络变化及其致糖尿病的巢式病例对照研究, 2020-2021

(12) 河南省科技厅, 科技攻关, 162102310541, 双酚A胚胎期暴露致子代胰岛功能异常与叶酸的保护作用, 2016-2017

(13) 郑州大学优秀青年人才创新团队, 2021-2025

(14) 郑州大学青年人才企业合作创新团队, 2021

(15) 片仔癀(上海)生物科技研发有限公司, 20230470A, 皮肤基础研究项目, 2023-2024

(16) 郑州市高新区管委会, 20190118A, 《郑州高新区健康城市建设两年规划(2019-2020年)》, 2018-2019

(17) 郑州市爱国卫生运动办公室, 20170416A, “健康郑州2030”规划纲要项目, 2017-2018

(18) 上海家化股份有限公司,20190259A,皮肤表面脂质组学基础与应用研究,2019-2020

(19) 上海家化股份有限公司,20190478A,护手产品干预长期暴露洗涤剂人群的皮肤表面脂质组学基础研究,2019-2020

(20) 上海家化股份有限公司,20190566A,不同年龄及生活方式的人群皮肤表面脂质组学基础研究,2019-2020

五、代表性成果

5.1 代表性论文

近三年,以第一/通讯作者在International Journal of EpidemiologyEnvironment International等发表论文40余篇。(*表示通讯作者,#表示第一作者)

1. Zhenxing Mao*.The relationship between cooking fuel use and sex hormone levels: A cross-sectional study and Mendelian randomization study. Sci Total Environ. 2024 Mar 25;918:170621

2. Zhenxing Mao*. Lipidomics reveals the effects of detergents on skin surface lipids in young adults. Dermatology. 2023 Nov 8. doi: 10.1159/000533872.

3. Zhenxing Mao*.Combined effects of organochlorine pesticides on type 2 diabetes mellitus: Insights from endocrine disrupting effects of hormones. Environ Pollut. 2023 Nov 7;341:122867. doi: 10.1016/j.envpol.2023.122867

4. Zhenxing Mao*.Higher HDL-C levels attenuated the association of plasma polybrominated diphenyl ethers with prediabetes and type 2 diabetes mellitus in rural Chinese adults. Ecotoxicol Environ Saf. 2023 Sep 28;265:115524.

5. Zhenxing Mao*.  Health risks of neonicotinoids chronic exposure and its association with glucose metabolism: A case-control study in rural China. Environ Pollut. 2023 Jul 17;334:122213. doi: 10.1016/j.envpol.2023.122213.

6. Zhenxing Mao*. Lipid Differences and Related Metabolism Present on the Hand Skin Surface of Different-Aged Asiatic Females-An Untargeted Metabolomics Study. Metabolites. 2023 Apr 13;13(4):553.

7. Zhenxing Mao*. Pesticide residues in common fruits and vegetables in Henan Province, China. Food Addit Contam Part B Surveill. 2023 Jun 7:1-9.

8. Zhenxing Mao*. Combined Effects of ESRα DNA Methylation and Progesterone on Glucose Metabolic Disorders: The Henan Rural Cohort Study. Nutrients. 2023;15(7):1659.

9. Zhenxing Mao*. Exposure to herbicides mixtures in relation to type 2 diabetes mellitus among Chinese rural population: Results from different statistical models. Ecotoxicol Environ Saf. 2023 Jun 8; 261:115109.

10. Zhenxing Mao*. Co-exposure of organophosphorus pesticides is associated with increased risk of type 2 diabetes mellitus in a Chinese population. Chemosphere. 2023 May 6;332:138865.

11. Zhenxing Mao*. Serum Progesterone is Negatively Associated with Hypertension and Blood Pressure Indicators Among Men and Postmenopausal Women. Horm Metab Res. 2023 Apr;55(4):273-283.

12. Zhenxing Mao*. Lipidomic Analysis of Hand Skin Surface Lipids Reveals Smoking-Related Skin Changes. Metabolites. 2023 Feb 9;13(2):254. 2023 Feb 9;13(2):254.

13. Zhenxing Mao*.Association between attitudes toward the COVID-19 vaccines and mental health among 140,259 college students in China. Z Gesundh Wiss. 2023 Jan 31:1-11.

14. Zhenxing Mao*. Worry and fear during the COVID-19 epidemic normalization: Analyzing prevalence and risk factors among 182,991 high school students in China. Psychol Sch. 2022 Nov 2:10.1002/pits.22817.

15. Zhenxing Mao*. Associations of residential greenness, ambient air pollution, biological sex, and glucocorticoids levels in rural China. Ecotoxicol Environ Saf. 2022 Sep 1;242:113945.

16. Zhenxing Mao*. corresponding author 1 Prevalence and risk factors of depressive symptoms among 140,259 college students during the COVID-19 epidemic normalization in China: A cross-sectional survey. Front Public Health. 2022 Aug 24;10:936700.

17. Zhenxing Mao*. The correlation between testosterone and stroke and the mediating role of blood pressure: The Henan rural cohort study. J Stroke Cerebrovasc Dis. 2022 Aug 16;31(10):106669.

18. Zhenxing Mao*. Lipidomic analysis reveals the effect of passive smoking on facial skin surface lipid in females. Chem Phys Lipids. 2022 Sep;247:105228.

19. Zhenxing Mao*. Serum Cortisol, 25 (OH)D, and Cardiovascular Risk Factors in Patients with Type 2 Diabetes Mellitus. Int J Endocrinol. 2022 Jun 18;2022:5680170. doi: 10.1155/2022/5680170. (中科院4区,IF2.803

20. Zhenxing Mao*. Ambient ozone exposure combined with residential greenness in relation to serum sex hormone levels in Chinese rural adults. Environ Res. 2022 Feb 5;210:112845.

21. Zhenxing Mao*.Associations of serum androgens with coronary heart disease and interaction with age: The Henan Rural Cohort Study. Nutr Metab Cardiovasc Dis. 2021 Aug 11:S0939-4753(21)00394-X.

22. Zhenxing Mao*. Interaction between testosterone and obesity on hypertension: A population-based cross-sectional study. Atherosclerosis. 2021 Jun 24; 330:14-21.

23. Zhenxing Mao*. Negative associations of morning serum cortisol levels with obesity: the Henan rural cohort study. Journal of endocrinological investigation 2021.

24. Zhenxing Mao*. Long-term exposure to particulate matter and residential greenness in relation to androgen and progesterone levels among rural Chinese adults. Environ Int. 2021 Aug;153:106483.

25. Zhenxing Mao*. Long-term exposure to PM1 and PM2.5 is associated with serum cortisone level and meat intake plays a moderation role. Ecotoxicol Environ Saf 2021, 215: 112133.

26. Zhenxing Mao*. Prevalence and Factors for Anxiety during the COVID-19 Pandemic among College Students in China, Int J Environ Res Public Health, 2021, 18, 4974

27. Zhengxing Mao*. Androgen receptor DNA methylation is an independent determinant of glucose metabolic disorders in women and testosterone plays moderation effects. J Diabetes. 2021, 13(4):282-291.

28. Zhenxing Mao*. Serum cortisone and glucocorticoid receptor gene (NR3C1) polymorphism in human dysglycemia. Hormones (Athens) 2020, 19(3): 385-393.

29. Zhenxing Mao*. Serum Vitamin D Affected Type 2 Diabetes though Altering Lipid Profile and Modified the Effects of Testosterone on Diabetes Status. Nutrients 2020, 13(1).

30. Zhenxing Mao*. Mineralocorticoids, glucose homeostasis and type 2 diabetes mellitus: The Henan Rural Cohort study. J Diabetes Complications. 2020,34(5): 107558.

31. Zhengxing Mao*. Dose-response association of sleep quality with anxiety symptoms in Chinese rural population: the Henan rural cohort. BMC Public Health. 2020 Aug 27;20(1):1297.

32. Zhenxing Mao*. Associations of SRD5A1 gene variants and testosterone with dysglycemia: Henan Rural Cohort study. Nutr Metab Cardiovasc Dis. 2019, 30(4): 599-607.

33. Zhenxing Mao*. The effect of progesterone and pregnenolone on diabetes status in Chinese rural population: a dose-response analysis from Henan Rural Cohort. Eur J Endocrinol. 2019, 181(6): 603-614.

34. Zhenxing Mao*. Gender-Specific Independent and Combined Effects of the Cortisol-to-Cortisone Ratio and 11-Deoxycortisol on Prediabetes and Type 2 Diabetes Mellitus: From the Henan Rural Cohort Study. J Diabetes Res. 2019 Jun 2; 4693817.

35. Zhenxing Mao*. Association of serum testosterone with different classes of glucose metabolism and the mediation effect of obesity: The Henan Rural Cohort Study. Diabetes Metab Res Rev. 2019, 35(5): e3133.

36. Zhenxing Mao#. Synergistic association of long-term ozone exposure and solid fuel use with biomarkers of advanced fibrosis. Environ Sci Pollut Res Int. 2023 Jun 29.

37. Zhenxing Mao#. Attitude toward COVID-19 vaccines and its association with depressive symptoms in 386,924 Chinese primary school students during COVID-19 epidemic normalization. J Psychosom Res. 2022 Nov;162:111021.

38. Zhenxing Mao#. Kitchen ventilation alleviated adverse associations of domestic fuel use and long-duration cooking with platelet indices as biomarkers of cardiovascular diseases. Sci Total Environ. 2022 Aug 15;834:155341.

39. Zhenxing Mao#. Association between mask wearing and anxiety symptoms during the outbreak of COVID 19: A large survey among 386,432 junior and senior high school students in China. J Psychosom Res. 2022 Feb;153:110709.

40. Zhenxing Mao#. Prevalence and associated factors of anxiety among 538,500 Chinese students during the outbreak of COVID-19: A web-based cross-sectional study. Psychiatry Res. 2021 Nov;305:114251.

41. Zhenxing Mao#. Combined effects of progesterone and SOCS3 DNA methylation on T2DM: a case-control study. Clin Epigenetics. 2021 Sep 26;13(1):181.

42. Zhenxing Mao#.Prevalence and risk factors for anxiety symptoms during the outbreak of COVID-19: A large survey among 373216 junior and senior high school students in China. Journal of Affective Disorders.2021

43. Zhenxing Mao#. Association between long-term exposure to ambient air pollutants and excessive daytime sleepiness in Chinese rural population: The Henan Rural Cohort Study. Chemosphere. 2020 Feb 3; 248:1-29.

44. Zhenxing Mao# Cohort Profile: The Henan Rural Cohort: a prospective study of chronic non-communicable diseases. Int J Epidemiol. 2019,48(6):1-11.

5.2 著作

(1) 毛振兴(副主编),Clinical Epidemiology(临床流行病学),郑州大学出版社,695千字,2020年。

(2) 毛振兴(副主编微囊藻毒素的生殖毒性研究进展郑州大学出版社,280千字,2022

(3) 毛振兴(编委),农药兽药污染与健康,湖北科学技术出版社,360千字,2020

5.3 专利和软著

(1) 蝶酰谷氨酸在防治环境内分泌干扰物致子代糖尿病中的应用,专利申请号:201510298602.4

(2) 毛振兴(1/1),心力衰竭中医风险评估系统V1.02021SR1319671, 2021.

(3) 毛振兴(1/1),心机梗死中医风险评估系统V1.02021SR1180911, 2021.

(4) 毛振兴(1/1),心绞痛中医风险评估系统V1.02021SR1522722, 2021.

(5) 毛振兴(1/1),脑出血中医风险评估系统V1.02021SR1678687, 2021.

(6) 毛振兴(1/5),脑梗死中医风险评估系统V1.02022SR0016077, 2022

5.4 学术奖励

(1) 毛振兴 (2/10),基于数据挖掘技术的2型糖尿病发病风险预测模型的构建及应用,河南省人民政府,河南省科技进步奖,贰等奖,20202020-J-101-R02/10

(2) 毛振兴 (1/1), Dose-response association of sleep quality with anxiety symptoms in Chinese rural population: the Henan rural cohort. 河南省教育厅,优秀科技论文奖,一等奖,2023 (豫教【202337113号)

(3) 毛振兴 (2/10),基于数据挖掘技术的2型糖尿病发病风险预测模型的构建及应用,河南省教育厅,河南省教育厅科技成果奖,一等奖,2020(豫教【20208238号)

(4) 毛振兴 (2/10),农村成年人群2型糖尿病流行特征与发病风险预测,河南省教育厅,河南省教育厅科技成果奖,一等奖,2019(豫教【201901500号)

(5) 毛振兴 (1/1), Paternal BPA exposure in early life alters Igf2 epigenetic status in sperm and induces pancreatic impairment in rat offspring,河南省教育厅,优秀科技论文奖,一等奖,2019年 (豫教【201901969号)

(6) 毛振兴 (4/15),农村成年人群高血压疾病负担与发病风险预测,河南省教育厅,河南省教育厅科技成果奖,一等奖,2017(豫教【20173882号)

联系方式:

Email-1mzx@zzu.edu.cn

Email-2maozhr@gmail.com